Treatments and supplements · Vaginal estrogen therapy

Is vaginal estrogen safe for vaginal dryness after menopause?

What we can tell you today: how thoroughly this has been studied.

Well studied

5 studies, including 2 that bring together the results of several trials in people.

5 Repeated evidence 2 studies

4 Large controlled trial 3 studies

This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.

Appears under: Menopause and hormones

The studies

5 Repeated evidence Hormonal Treatments and Vaginal Moisturizers for Genitourinary Syndrome of Menopause : A Systematic Review.
2024 · Annals of internal medicine
5 Repeated evidence Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis.
2025 · Revista brasileira de ginecologia e obstetricia : revis
4 Large controlled trial Efficacy and tolerability of a novel estradiol vaginal ring for relief of menopausal symptoms.
2003 · Obstetrics and gynecology · 113 participants
4 Large controlled trial The effect of a novel vaginal ring delivering oestradiol acetate on climacteric symptoms in postmenopausal women.
2003 · BJOG : an international journal of obstetrics and gynae · 159 participants
4 Large controlled trial Efficacy of sustained-release vaginal oestriol in alleviating urogenital and systemic climacteric complaints.
1991 · Maturitas · 109 participants