What actually works, and how well it is studied
132 treatments, supplements, foods and procedures — each with the number of studies behind it and how strong they are. Search for yours.
Where the evidence is strongest
Regular exercise / physical activity
How much exercise do I actually need to live longer?
Diet as a whole
Can what I eat slow down skin ageing?
GLP-1 medication
What do the weight-loss injections actually do?
Orlistat (Alli, Xenical)
Does orlistat really help you lose weight and what are the side effects?
Skin
26Collagen
Does collagen do anything for your skin?
Retinol and retinoids
Is retinol worth it?
Hyaluronic acid
Does hyaluronic acid really hydrate?
Peptides
Do peptide creams do anything?
Vitamin C
Does vitamin C serum work?
Niacinamide
What does niacinamide actually do?
Sunscreen
Does daily sunscreen slow skin ageing?
Botulinum toxin
What does Botox actually do to your skin?
Laser treatment
Do laser treatments work on ageing skin?
Hyaluronic acid fillers (Juvéderm, Restylane, Profhilo)
Do hyaluronic acid fillers work for nasolabial folds?
Microneedling (standalone)
Does microneedling really help with wrinkles?
Platelet-rich plasma (PRP)
Does PRP (vampire facial) actually work?
Poly-L-lactic acid filler (Sculptra)
Does Sculptra really stimulate collagen?
Radiofrequency skin tightening
Does radiofrequency actually tighten sagging skin?
Probiotics for skin (oral/topical)
Can probiotics improve my skin aging?
Laser resurfacing (ablative/non-ablative)
Which laser is best for wrinkles and skin resurfacing?
LED / photodynamic therapy
Does LED light therapy really reduce wrinkles?
Sun protection / sunscreen habits
Does daily sunscreen really prevent skin aging?
Microfocused ultrasound (Ultherapy)
Does Ultherapy actually lift sagging skin?
Retinol
Is retinol as good as prescription retinoids?
Collagen dermal filler (injectable)
Do collagen injections still work as fillers?
Exosome therapy
Are exosome treatments worth it for skin rejuvenation?
Stem cell-based treatments
Do stem cell injections actually rejuvenate skin?
Isotretinoin
Can isotretinoin improve sun-damaged skin?
Polynucleotide injections
Do polynucleotide injections improve skin quality?
Astaxanthin
Can astaxanthin protect skin from sun damage?
Hormones
24Phytoestrogens and isoflavones
Do soy and plant oestrogens help with menopause?
Estradiol therapy (patches, pills, gels, sprays)
Does estrogen therapy help with menopause symptoms and mood?
Hormone replacement therapy for skin
Does HRT actually improve my skin as I age?
Transdermal estrogen patch
Is the estrogen patch safer than pills for menopause symptoms?
Venlafaxine (Effexor)
Does venlafaxine help with hot flashes?
Oral micronized progesterone
Does progesterone help with night sweats and sleep?
Spironolactone
Does spironolactone help with hair loss or unwanted hair?
Norethindrone plus ethinyl estradiol
What does this hormone combo pill do for menopause symptoms?
Tibolone
What is tibolone and does it help menopause symptoms?
Combined oral contraceptives
Do birth control pills help with hair loss or hormonal acne?
Vaginal estrogen therapy
Is vaginal estrogen safe for vaginal dryness after menopause?
Conjugated estrogens with bazedoxifene (Duavee)
What is this combo drug with estrogen and bazedoxifene?
Black cohosh
Does black cohosh actually help with hot flashes?
Equol (S-equol supplement)
Does equol help with hot flashes?
Chinese herbal medicine
Do Chinese herbal remedies help with menopause symptoms?
Desvenlafaxine (Pristiq)
Does desvenlafaxine help with hot flashes?
Raloxifene (Evista)
Does raloxifene help protect my bones after menopause?
Vitamin E
Does vitamin E help with PCOS or hair issues?
Fezolinetant (Veozah)
Does the new non-hormone hot flash drug fezolinetant actually work?
Red clover extract
Does red clover help with hot flashes?
Cortisol tracking
Is my cortisol linked to my hot flashes?
Depo-medroxyprogesterone acetate
Can a progesterone shot help with hot flashes?
Curcumin
Can curcumin reduce hot flashes and anxiety?
GnRH agonist therapy
Does GnRH agonist therapy help hyperandrogenic women?
Sleep and mind
24Melatonin
Does melatonin actually help you sleep?
Magnesium
Does magnesium help you sleep?
Ashwagandha
Does ashwagandha do anything for stress and sleep?
Caffeine
How late can you drink coffee?
Omega-3
Is omega-3 worth taking?
Vitamin D
Do you need a vitamin D supplement?
Cognitive behavioural therapy (CBT)
Can CBT help with hot flashes and menopause symptoms?
Cognitive Behavioral Therapy for Insomnia (CBT-I)
Does CBT for insomnia actually work better than sleeping pills?
Sleep hygiene education
What is sleep hygiene and does teaching it actually help?
Light therapy
Can a light box fix my sleep schedule?
Digital and app-based CBT-I programs
Do sleep apps that use CBT really help with insomnia?
Biological age tests (DNA methylation etc.)
Can a test actually tell me my real biological age?
Mind-body exercise (yoga, tai chi)
Can yoga or tai chi ease menopause symptoms?
Nutrition and diet for brain health
Can changing my diet protect my brain as I get older?
Acupuncture and Traditional Chinese Medicine for sleep
Can acupuncture or Chinese herbal medicine fix my insomnia?
Menopausal hormone therapy for sleep
Can hormone therapy fix my menopause insomnia?
Sleep tracking devices and apps
Do sleep tracker apps actually help improve my sleep?
Sleep duration and quality
How much sleep do I really need to stay healthy long-term?
Combined lifestyle programs (diet+exercise+cognitive)
Do combined lifestyle programs really slow down mental decline?
Motivational interviewing / behaviour change counselling
Does talking to a coach really help me change my habits for good?
Z-drugs (Zolpidem and similar sleeping pills)
Are z-drugs like zolpidem safe for sleep long term?
B vitamins (B6, B12, folate)
Do B vitamins help prevent memory decline?
Sleep restriction therapy
What is sleep restriction therapy and does it help insomnia?
Brain stimulation (TMS/tDCS/tACS)
Can brain stimulation devices treat insomnia?
Weight and lifestyle
24GLP-1 medication
What do the weight-loss injections actually do?
Intermittent fasting
Does intermittent fasting work?
Mediterranean diet
Does the Mediterranean diet really help you live longer?
Regular exercise / physical activity
How much exercise do I actually need to live longer?
Behavioral weight-loss programs
Do structured behavior-change programs help you keep weight off?
Tirzepatide (Mounjaro, Zepbound)
Is tirzepatide better than semaglutide for weight loss?
Orlistat (Alli, Xenical)
Does orlistat really help you lose weight and what are the side effects?
Liraglutide (Saxenda)
How much weight can you lose on liraglutide?
Weight loss apps and digital health programs
Do phone apps actually help you lose weight and keep it off?
Mobile health apps and digital coaching
Can a health app actually help me change my habits?
Semaglutide (Ozempic, Wegovy)
Does semaglutide actually work for losing weight?
Diet and skin appearance
Can my diet change how my skin looks?
Resistance / strength training
Does lifting weights help me age better?
Aerobic exercise
Does aerobic exercise reduce hot flashes?
Bariatric surgery (gastric bypass, sleeve)
Does weight loss surgery keep the weight off better than medication?
Daily step counts / walking
How many steps a day should I aim for?
Cutting down sitting time
Does sitting all day undo the good of exercising?
Metformin
Can metformin help with weight loss if you are not diabetic?
Commercial weight loss programs
Are paid programs like Weight Watchers actually worth it?
Self-monitoring and self-weighing
Does weighing yourself regularly actually help you keep weight off?
Gut microbiome treatments
Can changing your gut bacteria help you lose weight?
Physical activity trackers / wearables
Does wearing a fitness tracker actually get me moving more?
Financial incentives for healthy behaviour
Would getting paid to be healthy actually work?
Workplace wellness programs
Do workplace health programs actually make a difference?
Food and nutrition
22Diet as a whole
Can what I eat slow down skin ageing?
Soy and isoflavones
Does soy help with skin ageing after menopause?
Intermittent fasting
Does intermittent fasting help with weight loss?
Time-restricted eating
Does eating only within a certain window help me lose weight?
Calorie and energy restriction
Does simply cutting calories work best for weight loss?
Soy and isoflavones
Does eating soy help with hot flushes and other menopause symptoms?
Calcium
Does calcium help with menopause symptoms or just bones?
Plant-based diet and whole soy foods
Would a plant-based diet with whole soy foods ease my menopause symptoms?
Curcumin
Can curcumin reduce hot flushes and anxiety in menopause?
Nutritional interventions for mood
Can changing what I eat ease my menopause anxiety or depression?
Diet and gut microbiome
Could changing my diet through the gut microbiome reduce hot flushes?
B vitamins (B12, B6, folate)
Do B vitamins help protect memory and thinking?
Astaxanthin
Does astaxanthin reduce fatigue and support brain function?
Time-restricted eating
Does eating only within a set time window improve mood and energy?
Fermented fruit extracts
Can fermented tropical fruit extracts help my hair?
Botanical hair-growth supplements
Do plant-based hair supplements actually work?
Collagen peptides
Do collagen peptides make my nails stronger?
Soy and phytoestrogens
Can soy protein help with menopausal hair changes?
Calcium
Does calcium make a difference to nail quality?
Mediterranean diet
Does the Mediterranean diet help me live longer?
Caloric restriction and fasting
Does eating less help me live longer and healthier?
Dietary inflammatory index
Does an anti-inflammatory way of eating help me live longer?
Hair
12Minoxidil
Does minoxidil regrow hair in women?
Herbal remedies for hair loss
Do herbal remedies work for hair loss?
Hair growth supplements (general)
Do hair growth supplements actually work?
5-alpha reductase inhibitors (finasteride, dutasteride)
Do finasteride or dutasteride help women with hair loss?
Low-level laser/LED therapy for hair
Do those laser combs and helmets really regrow hair?
Topical tacrolimus/calcipotriol/clobetasol
Do steroid creams like clobetasol or tacrolimus help alopecia areata?
Scalp antioxidant treatments
Do antioxidant scalp serums reduce hair shedding?
Fractional CO2 laser
Does CO2 laser help hair regrowth?
Collagen peptides for nails
Do collagen supplements really strengthen nails?
Zinc supplements
Does zinc help with hair loss?
Adipose-derived stromal vascular fraction / stem cells
Can fat-derived stem cell treatments regrow hair?
Intralesional steroid injections
Do steroid injections in the scalp help alopecia areata?
Nothing here matches that. The archive may still hold studies on it — try the topics.
This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.