Treatments and supplements · Polynucleotide injections
Do polynucleotide injections improve skin quality?
What we can tell you today: how thoroughly this has been studied.
The evidence stops at small studies
3 studies in people, but all of them small or without a comparison group. Enough to suspect something, too little to be sure.
3 Small study in people 3 studies
This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.
Appears under: Skin aging
The studies
- 3 Small study in people
Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial.
2022 · The Journal of dermatological treatment · 27 participants
- 3 Small study in people
Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study.
2023 · Journal of cosmetic dermatology · 20 participants
- 3 Small study in people
A Real-Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation.
2026 · Journal of cosmetic dermatology