Topic

Skin aging

The 200 studies that carry the evidence on this topic, ordered by weight: the stronger the evidence and the more the study was built on, the higher it stands.

all levels level 5 · 55 level 4 · 53 level 3 · 92

5 Repeated evidence A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging.
2023 · Phytomedicine : international journal of phytotherapy and ph
5 Repeated evidence Defining skin aging and its risk factors: a systematic review and meta-analysis.
2022 · Scientific reports
5 Repeated evidence Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis.
2023 · Nutrients · 1,721 participants
5 Repeated evidence Comparing Tretinoin to Other Topical Therapies in the Treatment of Skin Photoaging: A Systematic Review.
2024 · American journal of clinical dermatology
5 Repeated evidence The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series.
2025 · Medicina (Kaunas, Lithuania)
5 Repeated evidence Dietary interventions in skin ageing: a systematic review and meta-analysis.
2025 · Journal of physiological anthropology · manufacturer helped fund this
5 Repeated evidence Evaluating the effectiveness and safety of radiofrequency for face and neck rejuvenation: A systematic review.
2022 · Lasers in surgery and medicine
5 Repeated evidence Cosmeceuticals in photoaging: A review.
2024 · Skin research and technology : official journal of Internati
5 Repeated evidence Skin measurement devices to assess skin quality: A systematic review on reliability and validity.
2022 · Skin research and technology : official journal of Internati · 3,172 participants
5 Repeated evidence Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review.
2021 · Cells · 46 participants
5 Repeated evidence Home-based devices in dermatology: a systematic review of safety and efficacy.
2022 · Archives of dermatological research
5 Repeated evidence Efficacy of topical vitamin C in melasma and photoaging: A systematic review.
2023 · Journal of cosmetic dermatology · 139 participants
5 Repeated evidence Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatite (CaHA) in the Face: A Systematic Review.
2026 · Aesthetic plastic surgery
5 Repeated evidence Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis.
2025 · Scientific reports · 3,905 participants
5 Repeated evidence Microfocused Ultrasound With Visualization (MFU-V) Effectiveness and Safety: A Systematic Review and Meta-Analysis.
2025 · Aesthetic surgery journal · 785 participants
5 Repeated evidence Cosmeceuticals for antiaging: a systematic review of safety and efficacy.
2024 · Archives of dermatological research · 1,236 participants
5 Repeated evidence Intense Pulsed Light on skin rejuvenation: a systematic review.
2022 · Archives of dermatological research · 637 participants
5 Repeated evidence Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
2021 · Aesthetic plastic surgery
5 Repeated evidence Rejuvenating the periorbital area using platelet-rich plasma: a systematic review and meta-analysis.
2022 · Archives of dermatological research · 455 participants
5 Repeated evidence Systematic review and meta-analysis of randomized clinical trials comparing efficacy, safety, and satisfaction between ablative and non-ablative lasers in facial and hand rejuvenation/resurfacing.
2022 · Lasers in medical science · 124 participants
5 Repeated evidence Novel approaches for managing aged skin and nonmelanoma skin cancer.
2021 · Advanced drug delivery reviews
5 Repeated evidence Collagen supplementation for skin health: A mechanistic systematic review.
2021 · Journal of cosmetic dermatology
5 Repeated evidence Botulinum toxin type A for facial wrinkles.
2021 · The Cochrane database of systematic reviews · 1,471 participants
5 Repeated evidence Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
2025 · Indian journal of dermatology, venereology and leprology · 646 participants
5 Repeated evidence Exploring the Role of Herbal Compounds in Skin Aging: A Systematic Review of Topical Approaches.
2025 · Phytotherapy research : PTR
5 Repeated evidence Treatment of Solar Lentigines: A Systematic Review of Clinical Trials.
2025 · Journal of cosmetic dermatology · 3,234 participants
5 Repeated evidence Systematic Review of Platelet-Rich Plasma and Platelet-Rich Fibrin in Facial Rejuvenation.
2025 · Annals of plastic surgery · 514 participants
5 Repeated evidence The selection of hyaluronic acid when treating with the nasolabial fold: A meta-analysis.
2022 · Journal of cosmetic dermatology · 1,190 participants
5 Repeated evidence A Systematic Review of the Efficacy and Safety of Profhilo® and Profhilo® Body.
2026 · Plastic and aesthetic nursing · 278 participants
5 Repeated evidence The Effects of Facial Lipografting on Skin Quality: A Systematic Review.
2020 · Plastic and reconstructive surgery · 301 participants
5 Repeated evidence Appearance-based interventions to reduce ultraviolet exposure and/or increase sun protection intentions and behaviours: a systematic review and meta-analyses.
2013 · British journal of health psychology
5 Repeated evidence Intrinsic and extrinsic risk factors for sagging eyelids.
2014 · JAMA dermatology
5 Repeated evidence Optical Coherence Tomography Imaging of Normal, Chronologically Aged, Photoaged and Photodamaged Skin: A Systematic Review.
2015 · Dermatologic surgery : official publication for American Soc
5 Repeated evidence Efficacy and Safety of Centella Asiatica ( L. ) Urb. on Wrinkles: A Systematic Review of Published Data and Network Meta-Analysis.
2021 · Journal of cosmetic science
5 Repeated evidence The efficacy of various interventions as good strategies to reduce pain in botulinum neurotoxin A for wrinkles. A systematic review of the randomized controlled trials (RCTs).
2024 · Journal of cosmetic and laser therapy : official publication
5 Repeated evidence Light-Emitting Diode-Based Photodynamic Therapy for Photoaging, Scars, and Dyspigmentation: A Systematic Review.
2021 · Dermatologic surgery : official publication for American Soc
5 Repeated evidence Facial Wrinkles in Europeans: A Genome-Wide Association Study.
2019 · The Journal of investigative dermatology
5 Repeated evidence Astragalus membranaceus Extract as a Botanical Ingredient for Pigmentary and Anti-Aging Skincare: A Systematic Review.
2026 · Journal of drugs in dermatology : JDD
5 Repeated evidence Effects of GLP-1 Receptor Agonists on Skin Quality: A Comprehensive Literature Review.
2026 · Aesthetic plastic surgery
5 Repeated evidence Efficacy and Safety of Amino Acid-Enriched Hyaluronic Acid in Facial Rejuvenation: A Systematic Review and Meta-Analysis.
2026 · Journal of cosmetic dermatology · 11 participants
5 Repeated evidence Clinical Advances in Exosome-Based Therapies for Aesthetic Medicine: A Systematic Review and Meta-analysis of Human Clinical Trials.
2026 · Aesthetic surgery journal
5 Repeated evidence Beyond Wrinkles: A Systematic Review and Meta-analysis of Off-Label Aesthetic Uses of Botulinum Neurotoxin.
2026 · Annals of plastic surgery · 1,903 participants
5 Repeated evidence Laser Resurfacing at the Time of Facelift Surgery: A Systematic Review and Meta-Analysis.
2026 · Aesthetic surgery journal · 1,361 participants
5 Repeated evidence Cosmetic Botulinum Toxin A Injections to the Upper Face: A Systematic Review and Meta-Analysis of Clinical Studies.
2026 · Journal of cosmetic dermatology
5 Repeated evidence Optimizing Collagen Biostimulator Choice in LATAM: Expert Consensus on Patient Selection, Ethnic Skin Phenotypes, and Accessibility.
2025 · Journal of cosmetic dermatology
5 Repeated evidence Efficacy of formulations for treating hyperpigmentation: a systematic review and meta-analysis.
2025 · Archives of dermatological research · 337 participants
4 Large controlled trial Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study.
2024 · Journal of cosmetic dermatology · 100 participants
4 Large controlled trial A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
2023 · The Journal of dermatological treatment · 146 participants
5 Repeated evidence What influences the uptake of information to prevent skin cancer? A systematic review and synthesis of qualitative research.
2010 · Health education research
5 Repeated evidence Can dietary intake influence perception of and measured appearance? A systematic review.
2015 · Nutrition research (New York, N.Y.) · 4,741 participants
5 Repeated evidence SUPPLEMENT ARTICLE: Scientific and Clinical Insights into the Facial Application of Mineralizing Volcanic Water.
2022 · Journal of drugs in dermatology : JDD
5 Repeated evidence The Preventive Value of Sun Protection.
2022 · Current problems in dermatology · 1,621 participants
4 Large controlled trial Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults.
2026 · Scientific reports · 150 participants
4 Large controlled trial Prospective comparative clinical study: Efficacy evaluation of collagen combined with hyaluronic acid injections for tear trough deformity.
2024 · Journal of cosmetic dermatology · 2,023 participants
4 Large controlled trial A Randomized, Multicenter, Evaluator-blind Study to Evaluate the Safety and Effectiveness of VYC-12L Treatment for Skin Quality Improvements.
2023 · Dermatologic surgery : official publication for American Soc · 131 participants
4 Large controlled trial Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.
2016 · Journal of microbiology and biotechnology · 110 participants
5 Repeated evidence How effective are physical appearance interventions in changing smoking perceptions, attitudes and behaviours? A systematic review.
2013 · Tobacco control
5 Repeated evidence Hypo-collagenesis in photoaged skin predicts response to anti-aging cosmeceuticals.
2014 · Journal of cosmetic dermatology · 20 participants
4 Large controlled trial Efficacy and Safety of Two Resilient Hyaluronic Acid Fillers in the Treatment of Moderate-to-Severe Nasolabial Folds: A 64-Week, Prospective, Multicenter, Controlled, Randomized, Double-Blinded, and Within-Subject Study.
2021 · Dermatologic surgery : official publication for American Soc · 174 participants
4 Large controlled trial Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial.
2023 · Photobiomodulation, photomedicine, and laser surgery · 137 participants
5 Repeated evidence Photoprotective effect of botanicals and vitamins: A systematic review of clinical trials.
2016 · The Journal of dermatological treatment
4 Large controlled trial A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging.
2025 · Journal of cosmetic dermatology · 180 participants · manufacturer helped fund this
4 Large controlled trial Safety, Pharmacodynamic Response, and Treatment Satisfaction With OnabotulinumtoxinA 40 U, 60 U, and 80 U in Subjects With Moderate to Severe Dynamic Glabellar Lines.
2022 · Aesthetic surgery journal · 226 participants
4 Large controlled trial Effect of a Face-Aging Mobile App-Based Intervention on Skin Cancer Protection Behavior in Secondary Schools in Brazil: A Cluster-Randomized Clinical Trial.
2021 · JAMA dermatology · 1,573 participants · manufacturer helped fund this
4 Large controlled trial Oral consumption of Bonito fish-derived elastin peptide (VGPG Elastin ® ) improves biophysical properties in aging skin: A randomized, double-blinded, placebo-controlled study.
2024 · Skin research and technology : official journal of Internati · 100 participants
5 Repeated evidence [From the Cochrane Library: Improvement of photodamaged skin with retinoid creams and not with other local treatments].
2006 · Nederlands tijdschrift voor geneeskunde
4 Large controlled trial Efficacy and Safety of Collagen Filler for Intradermal Injection: A Randomized Prospective Controlled Multicenter Study.
2025 · Aesthetic plastic surgery · 480 participants
5 Repeated evidence Effect of tretinoin emollient cream on photodamaged skin: relationship between clinical improvement and skin irritation.
1996 · The British journal of dermatology
4 Large controlled trial Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
2021 · Nutrients · 151 participants
4 Large controlled trial Sunscreen and prevention of skin aging: a randomized trial.
2013 · Annals of internal medicine · 1,621 participants
4 Large controlled trial Internet-based photoaging within Australian pharmacies to promote smoking cessation: randomized controlled trial.
2013 · Journal of medical Internet research · 160 participants
4 Large controlled trial Efficacy and Safety of DaxibotulinumtoxinA for Injection in the Treatment of Glabellar Lines by Age and Race: Subgroup Analysis of the SAKURA Clinical Trials.
2023 · Aesthetic surgery journal · 2,785 participants
4 Large controlled trial A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.
2015 · Photomedicine and laser surgery · 136 participants
4 Large controlled trial Efficacy and safety of onabotulinumtoxinA for treating crow's feet lines alone or in combination with glabellar lines: a multicenter, randomized, controlled trial.
2015 · Dermatologic surgery : official publication for American Soc · 306 participants
4 Large controlled trial Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial.
2019 · Alternative therapies in health and medicine · 113 participants
4 Large controlled trial A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.
2021 · Journal of cosmetic dermatology · 100 participants
4 Large controlled trial Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage.
2011 · The British journal of dermatology · 139 participants
4 Large controlled trial A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles.
2010 · Journal of the American Academy of Dermatology · 117 participants
4 Large controlled trial A randomized, double-blind, controlled study evaluating the effects of two facial serums on skin aging.
2023 · Skin research and technology : official journal of Internati · 130 participants
4 Large controlled trial A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.
2026 · Nutrients · 112 participants · manufacturer helped fund this
4 Large controlled trial Effects of Heat-Killed Lactobacillus acidophilus IDCC 3302 on Skin Aging Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults.
2026 · Nutrients · 100 participants · manufacturer helped fund this
4 Large controlled trial Transitioning from Anti-aging to Skin Activation: Limiting Cellular Fatigue and Senescence for Skin Longevity.
2026 · Journal of drugs in dermatology : JDD · 400 participants
4 Large controlled trial Comparing patient satisfaction and pain control between vibration and topical anesthesia during botulinum toxin A injections: a randomized, double-blind, split-face clinical trial.
2026 · Journal of cosmetic and laser therapy : official publication · 100 participants
4 Large controlled trial Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study.
2026 · Aesthetic surgery journal · 174 participants · manufacturer helped fund this
4 Large controlled trial Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.
2026 · Aesthetic surgery journal · 100 participants · manufacturer helped fund this
4 Large controlled trial Assessment of skin photoaging with reflectance confocal microscopy.
2015 · Skin research and technology : official journal of Internati · 120 participants
4 Large controlled trial A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin.
2015 · Journal of cosmetic dermatology · 120 participants
4 Large controlled trial Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms.
2024 · Biomolecules · 104 participants
4 Large controlled trial Autologous cultured fibroblast injection for facial contour deformities: a prospective, placebo-controlled, Phase III clinical trial.
2007 · Dermatologic surgery : official publication for American Soc · 215 participants
4 Large controlled trial Validation of digital photographic reference scales for evaluating facial aging signs.
2018 · Skin research and technology : official journal of Internati · 350 participants
4 Large controlled trial Long-term results for incobotulinumtoxinA in the treatment of glabellar frown lines.
2013 · Dermatologic surgery : official publication for American Soc · 796 participants
4 Large controlled trial A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.
2010 · The British journal of dermatology · 196 participants
4 Large controlled trial Juvéderm injectable gel: a multicenter, double-blind, randomized study of safety and effectiveness.
2009 · Aesthetic surgery journal · 292 participants
4 Large controlled trial Combination 532-nm and 1064-nm lasers for noninvasive skin rejuvenation and toning.
2003 · Archives of dermatology · 150 participants
4 Large controlled trial Can the effectiveness of health promotion campaigns be improved using self-efficacy and self-affirmation interventions? An analysis of sun protection messages.
2012 · Psychology & health · 677 participants
4 Large controlled trial A Novel Matrikine-Like Micro-Protein Complex (MPC) Technology for Topical Skin Rejuvenation.
2017 · Journal of drugs in dermatology : JDD · 133 participants
4 Large controlled trial ArteFill: a long-lasting injectable wrinkle filler material--summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes.
2006 · Plastic and reconstructive surgery · 251 participants
4 Large controlled trial Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler.
2008 · Dermatologic surgery : official publication for American Soc · 149 participants
4 Large controlled trial Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions.
1999 · Dermatology (Basel, Switzerland) · 355 participants
4 Large controlled trial Does hormone therapy improve age-related skin changes in postmenopausal women? A randomized, double-blind, double-dummy, placebo-controlled multicenter study assessing the effects of norethindrone acetate and ethinyl estradiol in the improvement of mild to moderate age-related skin changes in postmenopausal women.
2008 · Journal of the American Academy of Dermatology · 165 participants
4 Large controlled trial Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial.
2010 · Dermatologic surgery : official publication for American Soc · 118 participants
4 Large controlled trial RimabotulinumtoxinB vs. onabotulinumtoxinA for the treatment of forehead lines: an evaluator-blind, randomized, pilot study.
2013 · Journal of the European Academy of Dermatology and Venereolo · 100 participants
4 Large controlled trial A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage.
2005 · Journal of the American Academy of Dermatology · 568 participants
4 Large controlled trial Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial.
2000 · Journal of the American Academy of Dermatology · 800 participants
3 Small study in people Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study.
2023 · Journal of cosmetic dermatology
4 Large controlled trial Climacteric skin ageing of the face--a prospective longitudinal comparative trial on the effect of oral hormone replacement therapy.
1999 · Maturitas · 140 participants
4 Large controlled trial Application of a topical biomimetic electrical signaling technology to photo-aging: a randomized, double-blind, placebo-controlled trial of a galvanic zinc-copper complex.
2012 · Journal of drugs in dermatology : JDD · 124 participants
4 Large controlled trial "Multi Light and Drugs": a new technique to treat face photoaging. Comparative study with photorejuvenation.
2008 · Lasers in medical science · 100 participants
4 Large controlled trial Clinical panel assessment of photodamaged skin treated with isotretinoin using photographs.
1992 · Archives of dermatology · 326 participants
3 Small study in people Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.
2020 · GeroScience
3 Small study in people Gene Analysis of Biostimulators: Poly-L-Lactic Acid Triggers Regeneration While Calcium Hydroxylapatite Induces Inflammation Upon Facial Injection.
2025 · Journal of drugs in dermatology : JDD · 21 participants
3 Small study in people Facial Skin Rejuvenation Using Poly- dl -Lactic Acid Injected With a Laser-Generated Needle-Free Microjet Injector.
2025 · Dermatologic surgery : official publication for American Soc
3 Small study in people Skin Anti-Aging Efficacy of Enzyme-Treated Supercritical Caviar Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
2024 · Nutrients
3 Small study in people Needleless laser injector versus needle injection for skin enhancement and rejuvenation effect of dermal filler.
2026 · Lasers in surgery and medicine
3 Small study in people Comparison of the effects of fractional microneedle radiofrequency and microneedling on modulating the senescent fibroblast milieu in aged skin.
2025 · Scientific reports · manufacturer helped fund this
3 Small study in people Radiofrequency Improves Facial Fine Lines by Thermal Effect: Damage or Just Stimulation?
2025 · Journal of cosmetic dermatology · 46 participants
3 Small study in people Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial.
2022 · The Journal of dermatological treatment · 27 participants
3 Small study in people Monopolar Radiofrequency for Facial Hyperpigmentation Treatment: An Integrated Retrospective Clinical Trial and Ex Vivo Study.
2026 · International journal of molecular sciences
3 Small study in people A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric.
2026 · Journal of cosmetic dermatology · 32 participants
3 Small study in people Anti-skin aging properties of protocatechuic acid in vitro and in vivo.
2021 · Journal of cosmetic dermatology
3 Small study in people A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity.
2021 · Journal of cosmetic dermatology · 12 participants
3 Small study in people Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial.
2023 · Nutrients
3 Small study in people A Randomized, Evaluator-Blinded, Multicenter Study to Compare Injectable Poly-D,L-Lactic Acid vs Hyaluronic Acid for Nasolabial Fold Augmentation.
2024 · Aesthetic surgery journal
3 Small study in people Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial.
2020 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Efficacy and Safety of Epidermidibacterium Keratini EPI-7 Derived Postbiotics in Skin Aging: A Prospective Clinical Study.
2023 · International journal of molecular sciences
3 Small study in people Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial.
2025 · The Journal of dermatological treatment · 31 participants
3 Small study in people Comparative analysis of erbium: glass 1550 nm and combined erbium: YAG & Nd: YAG lasers for perioral rejuvenation: a prospective study.
2025 · Lasers in medical science
3 Small study in people Safety and Efficacy of an Injectable Solution Enriched With Sodium Hyaluronate, Amino Acids, and Peptides in Relation to Superficial Facial Connective Tissues (Dermis and Retinacular Cutis).
2025 · Journal of cosmetic dermatology
3 Small study in people Comparing the Effectiveness of Platelet-Rich Plasma Alone Versus Combined With Microneedles or Radiofrequency for Neck Wrinkle Treatment.
2025 · Journal of cosmetic dermatology
3 Small study in people Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial.
2024 · Biomolecules
3 Small study in people Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A-induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study.
2024 · Journal of the American Academy of Dermatology
3 Small study in people Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study.
2023 · Journal of cosmetic dermatology · 20 participants
3 Small study in people Microneedling Radiofrequency Enhances Poly-L-Lactic Acid Penetration That Effectively Improves Facial Skin Laxity without Lipolysis.
2024 · Plastic and reconstructive surgery · 32 participants
3 Small study in people Comparative Bulk RNA-Seq Analysis of Poly-l-Lactic Acid Versus Calcium Hydroxylapatite Reveals a Novel, Adipocyte-Mediated Regenerative Mechanism of Action Unique to PLLA.
2024 · Dermatologic surgery : official publication for American Soc · 21 participants
3 Small study in people Safety and Efficacy of Poly-L-Lactic Acid Filler (Gana V vs. Sculptra) Injection for Correction of the Nasolabial Fold: A Double-Blind, Non-Inferiority, Randomized, Split-Face Controlled Trial.
2023 · Aesthetic plastic surgery
3 Small study in people A Real-Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation.
2026 · Journal of cosmetic dermatology
3 Small study in people OS-01 Peptide Topical Formulation Improves Skin Barrier Function and Reduces Systemic Inflammation Markers: A Pilot 12-Week Clinical Trial.
2025 · Journal of cosmetic dermatology
3 Small study in people Efficacy and Safety of Poly-L-lactic Acid for Midface Rejuvenation: A 12-Month Split-face Controlled Evaluation With 3D Imaging and Patient-reported Outcomes.
2026 · Aesthetic surgery journal
3 Small study in people A New 675 nm Laser Device in the Treatment of Facial Aging: A Prospective Observational Study.
2021 · Photobiomodulation, photomedicine, and laser surgery · 22 participants
3 Small study in people The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
2018 · Nutrients
3 Small study in people Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing.
2020 · The British journal of dermatology · 44 participants
3 Small study in people Evaluation of the Performance and Safety of a New Micro-Needle Technology in Comparison With the Classic Needle on the Antiaging Effects of a Biorevitalizing Solution: A Randomized Split Face/Neck Study.
2024 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Hand Rejuvenation with Customizable Hybrid Fillers: Premixed Calcium Hydroxyapatite and Hyaluronic Acid.
2024 · Aesthetic plastic surgery
3 Small study in people Oyster hydrolysate ameliorates UVB-induced skin dehydration and barrier dysfunction.
2024 · Life sciences
3 Small study in people Neuromuscular electrical stimulation for facial wrinkles and sagging: The 8-week prospective, split-face, controlled trial in Asians.
2024 · Journal of cosmetic dermatology
3 Small study in people The evidence from in vitro primary fibroblasts and a randomized, double-blind, placebo-controlled clinical trial of tuna collagen peptides intake on skin health.
2024 · Journal of cosmetic dermatology · 72 participants
3 Small study in people Annurca Apple Oleolite as Functional Ingredient for the Formulation of Cosmetics with Skin-Antiaging Activity.
2024 · International journal of molecular sciences · 40 participants
3 Small study in people Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract ( Vaccinium myrtillus ): A Randomized, Double-Blind, Placebo-Controlled Trial.
2024 · Nutrients · 66 participants
3 Small study in people Topical Lactiplantibacillus plantarum LB244R® ointment alleviates skin aging: An exploratory trial.
2023 · Journal of cosmetic dermatology · 21 participants
3 Small study in people Impact on facial skin aging signs of a 1-year standardized photoprotection over a classical skin care routine in skin phototypes II-VI individuals: A prospective randomized trial.
2023 · Journal of the European Academy of Dermatology and Venereolo · manufacturer helped fund this
3 Small study in people Fermented pomegranate extracts protect against oxidative stress and aging of skin.
2022 · Journal of cosmetic dermatology · 40 participants
3 Small study in people A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties.
2022 · Marine drugs
3 Small study in people Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study.
2021 · Molecules (Basel, Switzerland) · manufacturer helped fund this
3 Small study in people Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity.
2021 · International journal of cosmetic science
3 Small study in people Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study.
2024 · Medicina (Kaunas, Lithuania) · 70 participants
3 Small study in people Microneedle fractional radiofrequency associated with drug delivery for facial atrophic acne scars and skin rejuvenation.
2024 · Journal of cosmetic and laser therapy : official publication
3 Small study in people A study of anti-wrinkle functions and improvement of cream with Phaseolus angularis.
2024 · International journal of cosmetic science
3 Small study in people Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA TM : A Randomized, Double-Blind, Placebo Comparative Clinical Trial.
2024 · Nutrients · 51 participants
3 Small study in people Dietary supplementation with a wheat polar lipid complex improves skin conditions in women with dry skin and mild-to-moderate skin aging.
2024 · Journal of cosmetic dermatology · 24 participants
3 Small study in people Effect of Topical Human Platelet Extract (HPE) for Facial Skin Rejuvenation: A Histological Study of Collagen and Elastin.
2024 · Journal of drugs in dermatology : JDD
3 Small study in people High molecular weight hyaluronic acid vectorised with clay provides long-term hydration and reduces skin brightness.
2024 · Skin research and technology : official journal of Internati
3 Small study in people Supramolecular Salicylic Acid Alleviates Skin Photoaging by Increasing Collagen Density and Elasticity.
2025 · Aesthetic plastic surgery · 36 participants
3 Small study in people A Prospective, Randomized, Double-Blind, Split-Face Trial Evaluating the Effects of Pre-Conditioning With a TriHex Technology Serum Nectar 2.0 Versus a Vehicle in Subjects Undergoing Elective Facelift Surgery.
2025 · Journal of cosmetic dermatology
3 Small study in people Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
2026 · Frontiers in aging · 134 participants
3 Small study in people Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin.
2025 · Photodermatology, photoimmunology & photomedicine
3 Small study in people Efficacy of Natural β-Carotene Chewable Tablets Derived from Banana ( Musa AA) Pulp in Reducing UV-Induced Skin Erythema.
2025 · Nutrients
3 Small study in people Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing: A Double-blind, Randomised, Placebo-controlled Clinical Study.
2025 · Current medicinal chemistry
3 Small study in people Comparative Effects of Facial Roller and Gua Sha Massage on Facial Contour, Muscle Tone, and Skin Elasticity: Randomized Controlled Trial.
2025 · Journal of cosmetic dermatology · 17 participants
3 Small study in people A Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF).
2026 · Skin research and technology : official journal of Internati · 33 participants · manufacturer helped fund this
3 Small study in people Biological effects of rutin on skin aging.
2017 · International journal of molecular medicine · 40 participants
3 Small study in people Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study.
2022 · Photochemistry and photobiology
3 Small study in people Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.
2017 · Journal of the science of food and agriculture
3 Small study in people Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy.
2021 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Prospective Evaluation of Mango Fruit Intake on Facial Wrinkles and Erythema in Postmenopausal Women: A Randomized Clinical Pilot Study.
2021 · Nutrients
3 Small study in people Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels-A Randomized, Double-Blind, Placebo-Controlled Trial.
2019 · Marine drugs
3 Small study in people Microinjections with hyaluronic acid in combination with glycerol: How do they influence biophysical viscoelastic skin properties?
2022 · Skin research and technology : official journal of Internati · manufacturer helped fund this
3 Small study in people Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin.
2021 · Journal of drugs in dermatology : JDD
3 Small study in people Advances in dermatology using DNA aptamer "Aptamin C" innovation: Oxidative stress prevention and effect maximization of vitamin C through antioxidation.
2021 · Journal of cosmetic dermatology
3 Small study in people Indoor PM 2.5 exposure affects skin aging manifestation in a Chinese population.
2019 · Scientific reports · 1,003 participants
3 Small study in people Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin.
2019 · Journal of the American Academy of Dermatology
3 Small study in people Ultrasound rejuvenation for upper facial skin: A randomized blinded prospective study.
2024 · Journal of cosmetic dermatology · 42 participants
3 Small study in people A prospective and randomized study comparing ultrasound-guided real time injection to conventional blind injection of botulinum neurotoxin for glabellar wrinkles.
2024 · Journal of cosmetic dermatology · 40 participants
3 Small study in people Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream.
2024 · Skin research and technology : official journal of Internati
3 Small study in people Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation.
2024 · Journal of cosmetic dermatology · 26 participants · manufacturer helped fund this
3 Small study in people Novel Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract provides potent skin benefits in vitro and protects skin from aging.
2024 · Journal of cosmetic dermatology
3 Small study in people Anti-wrinkle efficacy of standardized phenolic acids polymer extract (PAPE) from propolis: Implications for antiaging and skin health.
2024 · Journal of cosmetic dermatology
3 Small study in people The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial.
2022 · Aging · 70 participants · manufacturer helped fund this
3 Small study in people A Randomized Double-Blind, Placebo-Controlled Study to Evaluate the Anti-Skin-Aging Effect of LactoSporin - The Extracellular Metabolite from Bacillus coagulans ( Weizmannia coagulans ) MTCC 5856 in Healthy Female Volunteers.
2023 · Clinical, cosmetic and investigational dermatology · 56 participants
3 Small study in people Randomized, Controlled, Multicentered, Double-Blind Investigation of Injectable Poly-L-Lactic Acid for Improving Skin Quality.
2019 · Dermatologic surgery : official publication for American Soc
3 Small study in people Temporal Variation of the Facial Skin Microbiome: A 2-Year Longitudinal Study in Healthy Adults.
2021 · Plastic and reconstructive surgery
3 Small study in people Combination of Calcium Hydroxylapatite Diluted With Normal Saline and Microfocused Ultrasound With Visualization for Skin Tightening.
2021 · Journal of drugs in dermatology : JDD · 20 participants
3 Small study in people Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles.
2020 · Phytotherapy research : PTR · 31 participants
3 Small study in people Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial.
2022 · JAMA dermatology · 24 participants · manufacturer helped fund this
3 Small study in people Comparison of 1064-nm and Dual-Wavelength (532/1064-nm) Picosecond-Domain Nd:YAG Lasers in the Treatment of Facial Photoaging: A Randomized Controlled Split-Face Study.
2022 · Lasers in surgery and medicine
3 Small study in people Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.
2020 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler.
2015 · Journal of drugs in dermatology : JDD
3 Small study in people Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split-face comparative study.
2019 · International journal of dermatology
3 Small study in people 2-kDa hyaluronan ameliorates human facial wrinkles through increased dermal collagen density related to promotion of collagen remodeling.
2023 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Effects of a Combination of Water-Soluble CoenzymeQ10 and Collagen on Skin Parameters and Condition:Results of a Randomised, Placebo-Controlled,Double-Blind Study.
2020 · Nutrients · 17 participants
3 Small study in people Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study.
2021 · Nutrients · 20 participants · manufacturer helped fund this