Topic

Skin aging

The 92 studies that carry the evidence on this topic, ordered by weight: the stronger the evidence and the more the study was built on, the higher it stands.

all levels level 5 · 55 level 4 · 53 level 3 · 92

3 Small study in people Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study.
2023 · Journal of cosmetic dermatology
3 Small study in people Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.
2020 · GeroScience
3 Small study in people Gene Analysis of Biostimulators: Poly-L-Lactic Acid Triggers Regeneration While Calcium Hydroxylapatite Induces Inflammation Upon Facial Injection.
2025 · Journal of drugs in dermatology : JDD · 21 participants
3 Small study in people Facial Skin Rejuvenation Using Poly- dl -Lactic Acid Injected With a Laser-Generated Needle-Free Microjet Injector.
2025 · Dermatologic surgery : official publication for American Soc
3 Small study in people Skin Anti-Aging Efficacy of Enzyme-Treated Supercritical Caviar Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
2024 · Nutrients
3 Small study in people Needleless laser injector versus needle injection for skin enhancement and rejuvenation effect of dermal filler.
2026 · Lasers in surgery and medicine
3 Small study in people Comparison of the effects of fractional microneedle radiofrequency and microneedling on modulating the senescent fibroblast milieu in aged skin.
2025 · Scientific reports · manufacturer helped fund this
3 Small study in people Radiofrequency Improves Facial Fine Lines by Thermal Effect: Damage or Just Stimulation?
2025 · Journal of cosmetic dermatology · 46 participants
3 Small study in people Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial.
2022 · The Journal of dermatological treatment · 27 participants
3 Small study in people A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric.
2026 · Journal of cosmetic dermatology · 32 participants
3 Small study in people Monopolar Radiofrequency for Facial Hyperpigmentation Treatment: An Integrated Retrospective Clinical Trial and Ex Vivo Study.
2026 · International journal of molecular sciences
3 Small study in people Anti-skin aging properties of protocatechuic acid in vitro and in vivo.
2021 · Journal of cosmetic dermatology
3 Small study in people A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity.
2021 · Journal of cosmetic dermatology · 12 participants
3 Small study in people Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial.
2023 · Nutrients
3 Small study in people A Randomized, Evaluator-Blinded, Multicenter Study to Compare Injectable Poly-D,L-Lactic Acid vs Hyaluronic Acid for Nasolabial Fold Augmentation.
2024 · Aesthetic surgery journal
3 Small study in people Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial.
2020 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Efficacy and Safety of Epidermidibacterium Keratini EPI-7 Derived Postbiotics in Skin Aging: A Prospective Clinical Study.
2023 · International journal of molecular sciences
3 Small study in people Comparative analysis of erbium: glass 1550 nm and combined erbium: YAG & Nd: YAG lasers for perioral rejuvenation: a prospective study.
2025 · Lasers in medical science
3 Small study in people Safety and Efficacy of an Injectable Solution Enriched With Sodium Hyaluronate, Amino Acids, and Peptides in Relation to Superficial Facial Connective Tissues (Dermis and Retinacular Cutis).
2025 · Journal of cosmetic dermatology
3 Small study in people Comparing the Effectiveness of Platelet-Rich Plasma Alone Versus Combined With Microneedles or Radiofrequency for Neck Wrinkle Treatment.
2025 · Journal of cosmetic dermatology
3 Small study in people Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial.
2025 · The Journal of dermatological treatment · 31 participants
3 Small study in people Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A-induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study.
2024 · Journal of the American Academy of Dermatology
3 Small study in people Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial.
2024 · Biomolecules
3 Small study in people Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study.
2023 · Journal of cosmetic dermatology · 20 participants
3 Small study in people Comparative Bulk RNA-Seq Analysis of Poly-l-Lactic Acid Versus Calcium Hydroxylapatite Reveals a Novel, Adipocyte-Mediated Regenerative Mechanism of Action Unique to PLLA.
2024 · Dermatologic surgery : official publication for American Soc · 21 participants
3 Small study in people Microneedling Radiofrequency Enhances Poly-L-Lactic Acid Penetration That Effectively Improves Facial Skin Laxity without Lipolysis.
2024 · Plastic and reconstructive surgery · 32 participants
3 Small study in people Safety and Efficacy of Poly-L-Lactic Acid Filler (Gana V vs. Sculptra) Injection for Correction of the Nasolabial Fold: A Double-Blind, Non-Inferiority, Randomized, Split-Face Controlled Trial.
2023 · Aesthetic plastic surgery
3 Small study in people Efficacy and Safety of Poly-L-lactic Acid for Midface Rejuvenation: A 12-Month Split-face Controlled Evaluation With 3D Imaging and Patient-reported Outcomes.
2026 · Aesthetic surgery journal
3 Small study in people OS-01 Peptide Topical Formulation Improves Skin Barrier Function and Reduces Systemic Inflammation Markers: A Pilot 12-Week Clinical Trial.
2025 · Journal of cosmetic dermatology
3 Small study in people A Real-Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation.
2026 · Journal of cosmetic dermatology
3 Small study in people A New 675 nm Laser Device in the Treatment of Facial Aging: A Prospective Observational Study.
2021 · Photobiomodulation, photomedicine, and laser surgery · 22 participants
3 Small study in people The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
2018 · Nutrients
3 Small study in people Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing.
2020 · The British journal of dermatology · 44 participants
3 Small study in people Oyster hydrolysate ameliorates UVB-induced skin dehydration and barrier dysfunction.
2024 · Life sciences
3 Small study in people Neuromuscular electrical stimulation for facial wrinkles and sagging: The 8-week prospective, split-face, controlled trial in Asians.
2024 · Journal of cosmetic dermatology
3 Small study in people Annurca Apple Oleolite as Functional Ingredient for the Formulation of Cosmetics with Skin-Antiaging Activity.
2024 · International journal of molecular sciences · 40 participants
3 Small study in people The evidence from in vitro primary fibroblasts and a randomized, double-blind, placebo-controlled clinical trial of tuna collagen peptides intake on skin health.
2024 · Journal of cosmetic dermatology · 72 participants
3 Small study in people Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract ( Vaccinium myrtillus ): A Randomized, Double-Blind, Placebo-Controlled Trial.
2024 · Nutrients · 66 participants
3 Small study in people Hand Rejuvenation with Customizable Hybrid Fillers: Premixed Calcium Hydroxyapatite and Hyaluronic Acid.
2024 · Aesthetic plastic surgery
3 Small study in people Evaluation of the Performance and Safety of a New Micro-Needle Technology in Comparison With the Classic Needle on the Antiaging Effects of a Biorevitalizing Solution: A Randomized Split Face/Neck Study.
2024 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Topical Lactiplantibacillus plantarum LB244R® ointment alleviates skin aging: An exploratory trial.
2023 · Journal of cosmetic dermatology · 21 participants
3 Small study in people Impact on facial skin aging signs of a 1-year standardized photoprotection over a classical skin care routine in skin phototypes II-VI individuals: A prospective randomized trial.
2023 · Journal of the European Academy of Dermatology and Venereolo · manufacturer helped fund this
3 Small study in people A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties.
2022 · Marine drugs
3 Small study in people Fermented pomegranate extracts protect against oxidative stress and aging of skin.
2022 · Journal of cosmetic dermatology · 40 participants
3 Small study in people Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study.
2021 · Molecules (Basel, Switzerland) · manufacturer helped fund this
3 Small study in people Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity.
2021 · International journal of cosmetic science
3 Small study in people A study of anti-wrinkle functions and improvement of cream with Phaseolus angularis.
2024 · International journal of cosmetic science
3 Small study in people Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA TM : A Randomized, Double-Blind, Placebo Comparative Clinical Trial.
2024 · Nutrients · 51 participants
3 Small study in people High molecular weight hyaluronic acid vectorised with clay provides long-term hydration and reduces skin brightness.
2024 · Skin research and technology : official journal of Internati
3 Small study in people Dietary supplementation with a wheat polar lipid complex improves skin conditions in women with dry skin and mild-to-moderate skin aging.
2024 · Journal of cosmetic dermatology · 24 participants
3 Small study in people Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study.
2024 · Medicina (Kaunas, Lithuania) · 70 participants
3 Small study in people Microneedle fractional radiofrequency associated with drug delivery for facial atrophic acne scars and skin rejuvenation.
2024 · Journal of cosmetic and laser therapy : official publication
3 Small study in people Effect of Topical Human Platelet Extract (HPE) for Facial Skin Rejuvenation: A Histological Study of Collagen and Elastin.
2024 · Journal of drugs in dermatology : JDD
3 Small study in people Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing: A Double-blind, Randomised, Placebo-controlled Clinical Study.
2025 · Current medicinal chemistry
3 Small study in people Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin.
2025 · Photodermatology, photoimmunology & photomedicine
3 Small study in people Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
2026 · Frontiers in aging · 134 participants
3 Small study in people Efficacy of Natural β-Carotene Chewable Tablets Derived from Banana ( Musa AA) Pulp in Reducing UV-Induced Skin Erythema.
2025 · Nutrients
3 Small study in people A Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF).
2026 · Skin research and technology : official journal of Internati · 33 participants · manufacturer helped fund this
3 Small study in people Supramolecular Salicylic Acid Alleviates Skin Photoaging by Increasing Collagen Density and Elasticity.
2025 · Aesthetic plastic surgery · 36 participants
3 Small study in people Comparative Effects of Facial Roller and Gua Sha Massage on Facial Contour, Muscle Tone, and Skin Elasticity: Randomized Controlled Trial.
2025 · Journal of cosmetic dermatology · 17 participants
3 Small study in people A Prospective, Randomized, Double-Blind, Split-Face Trial Evaluating the Effects of Pre-Conditioning With a TriHex Technology Serum Nectar 2.0 Versus a Vehicle in Subjects Undergoing Elective Facelift Surgery.
2025 · Journal of cosmetic dermatology
3 Small study in people Biological effects of rutin on skin aging.
2017 · International journal of molecular medicine · 40 participants
3 Small study in people Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study.
2022 · Photochemistry and photobiology
3 Small study in people Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.
2017 · Journal of the science of food and agriculture
3 Small study in people Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy.
2021 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Prospective Evaluation of Mango Fruit Intake on Facial Wrinkles and Erythema in Postmenopausal Women: A Randomized Clinical Pilot Study.
2021 · Nutrients
3 Small study in people Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels-A Randomized, Double-Blind, Placebo-Controlled Trial.
2019 · Marine drugs
3 Small study in people Microinjections with hyaluronic acid in combination with glycerol: How do they influence biophysical viscoelastic skin properties?
2022 · Skin research and technology : official journal of Internati · manufacturer helped fund this
3 Small study in people Advances in dermatology using DNA aptamer "Aptamin C" innovation: Oxidative stress prevention and effect maximization of vitamin C through antioxidation.
2021 · Journal of cosmetic dermatology
3 Small study in people Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin.
2021 · Journal of drugs in dermatology : JDD
3 Small study in people Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin.
2019 · Journal of the American Academy of Dermatology
3 Small study in people Indoor PM 2.5 exposure affects skin aging manifestation in a Chinese population.
2019 · Scientific reports · 1,003 participants
3 Small study in people Novel Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract provides potent skin benefits in vitro and protects skin from aging.
2024 · Journal of cosmetic dermatology
3 Small study in people Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream.
2024 · Skin research and technology : official journal of Internati
3 Small study in people A prospective and randomized study comparing ultrasound-guided real time injection to conventional blind injection of botulinum neurotoxin for glabellar wrinkles.
2024 · Journal of cosmetic dermatology · 40 participants
3 Small study in people Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation.
2024 · Journal of cosmetic dermatology · 26 participants · manufacturer helped fund this
3 Small study in people Anti-wrinkle efficacy of standardized phenolic acids polymer extract (PAPE) from propolis: Implications for antiaging and skin health.
2024 · Journal of cosmetic dermatology
3 Small study in people Ultrasound rejuvenation for upper facial skin: A randomized blinded prospective study.
2024 · Journal of cosmetic dermatology · 42 participants
3 Small study in people The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial.
2022 · Aging · 70 participants · manufacturer helped fund this
3 Small study in people A Randomized Double-Blind, Placebo-Controlled Study to Evaluate the Anti-Skin-Aging Effect of LactoSporin - The Extracellular Metabolite from Bacillus coagulans ( Weizmannia coagulans ) MTCC 5856 in Healthy Female Volunteers.
2023 · Clinical, cosmetic and investigational dermatology · 56 participants
3 Small study in people Randomized, Controlled, Multicentered, Double-Blind Investigation of Injectable Poly-L-Lactic Acid for Improving Skin Quality.
2019 · Dermatologic surgery : official publication for American Soc
3 Small study in people Temporal Variation of the Facial Skin Microbiome: A 2-Year Longitudinal Study in Healthy Adults.
2021 · Plastic and reconstructive surgery
3 Small study in people Combination of Calcium Hydroxylapatite Diluted With Normal Saline and Microfocused Ultrasound With Visualization for Skin Tightening.
2021 · Journal of drugs in dermatology : JDD · 20 participants
3 Small study in people Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles.
2020 · Phytotherapy research : PTR · 31 participants
3 Small study in people Comparison of 1064-nm and Dual-Wavelength (532/1064-nm) Picosecond-Domain Nd:YAG Lasers in the Treatment of Facial Photoaging: A Randomized Controlled Split-Face Study.
2022 · Lasers in surgery and medicine
3 Small study in people Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial.
2022 · JAMA dermatology · 24 participants · manufacturer helped fund this
3 Small study in people Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.
2020 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler.
2015 · Journal of drugs in dermatology : JDD
3 Small study in people Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split-face comparative study.
2019 · International journal of dermatology
3 Small study in people 2-kDa hyaluronan ameliorates human facial wrinkles through increased dermal collagen density related to promotion of collagen remodeling.
2023 · Journal of cosmetic dermatology · manufacturer helped fund this
3 Small study in people Effects of a Combination of Water-Soluble CoenzymeQ10 and Collagen on Skin Parameters and Condition:Results of a Randomised, Placebo-Controlled,Double-Blind Study.
2020 · Nutrients · 17 participants
3 Small study in people Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study.
2021 · Nutrients · 20 participants · manufacturer helped fund this