Topic

Skin aging

The 53 studies that carry the evidence on this topic, ordered by weight: the stronger the evidence and the more the study was built on, the higher it stands.

all levels level 5 · 55 level 4 · 53 level 3 · 92

4 Large controlled trial Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study.
2024 · Journal of cosmetic dermatology · 100 participants
4 Large controlled trial A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
2023 · The Journal of dermatological treatment · 146 participants
4 Large controlled trial Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults.
2026 · Scientific reports · 150 participants
4 Large controlled trial Prospective comparative clinical study: Efficacy evaluation of collagen combined with hyaluronic acid injections for tear trough deformity.
2024 · Journal of cosmetic dermatology · 2,023 participants
4 Large controlled trial A Randomized, Multicenter, Evaluator-blind Study to Evaluate the Safety and Effectiveness of VYC-12L Treatment for Skin Quality Improvements.
2023 · Dermatologic surgery : official publication for American Soc · 131 participants
4 Large controlled trial Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.
2016 · Journal of microbiology and biotechnology · 110 participants
4 Large controlled trial Efficacy and Safety of Two Resilient Hyaluronic Acid Fillers in the Treatment of Moderate-to-Severe Nasolabial Folds: A 64-Week, Prospective, Multicenter, Controlled, Randomized, Double-Blinded, and Within-Subject Study.
2021 · Dermatologic surgery : official publication for American Soc · 174 participants
4 Large controlled trial Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial.
2023 · Photobiomodulation, photomedicine, and laser surgery · 137 participants
4 Large controlled trial A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging.
2025 · Journal of cosmetic dermatology · 180 participants · manufacturer helped fund this
4 Large controlled trial Safety, Pharmacodynamic Response, and Treatment Satisfaction With OnabotulinumtoxinA 40 U, 60 U, and 80 U in Subjects With Moderate to Severe Dynamic Glabellar Lines.
2022 · Aesthetic surgery journal · 226 participants
4 Large controlled trial Effect of a Face-Aging Mobile App-Based Intervention on Skin Cancer Protection Behavior in Secondary Schools in Brazil: A Cluster-Randomized Clinical Trial.
2021 · JAMA dermatology · 1,573 participants · manufacturer helped fund this
4 Large controlled trial Oral consumption of Bonito fish-derived elastin peptide (VGPG Elastin ® ) improves biophysical properties in aging skin: A randomized, double-blinded, placebo-controlled study.
2024 · Skin research and technology : official journal of Internati · 100 participants
4 Large controlled trial Efficacy and Safety of Collagen Filler for Intradermal Injection: A Randomized Prospective Controlled Multicenter Study.
2025 · Aesthetic plastic surgery · 480 participants
4 Large controlled trial Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
2021 · Nutrients · 151 participants
4 Large controlled trial Sunscreen and prevention of skin aging: a randomized trial.
2013 · Annals of internal medicine · 1,621 participants
4 Large controlled trial Internet-based photoaging within Australian pharmacies to promote smoking cessation: randomized controlled trial.
2013 · Journal of medical Internet research · 160 participants
4 Large controlled trial Efficacy and Safety of DaxibotulinumtoxinA for Injection in the Treatment of Glabellar Lines by Age and Race: Subgroup Analysis of the SAKURA Clinical Trials.
2023 · Aesthetic surgery journal · 2,785 participants
4 Large controlled trial A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.
2015 · Photomedicine and laser surgery · 136 participants
4 Large controlled trial Efficacy and safety of onabotulinumtoxinA for treating crow's feet lines alone or in combination with glabellar lines: a multicenter, randomized, controlled trial.
2015 · Dermatologic surgery : official publication for American Soc · 306 participants
4 Large controlled trial Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial.
2019 · Alternative therapies in health and medicine · 113 participants
4 Large controlled trial A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.
2021 · Journal of cosmetic dermatology · 100 participants
4 Large controlled trial Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage.
2011 · The British journal of dermatology · 139 participants
4 Large controlled trial A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles.
2010 · Journal of the American Academy of Dermatology · 117 participants
4 Large controlled trial A randomized, double-blind, controlled study evaluating the effects of two facial serums on skin aging.
2023 · Skin research and technology : official journal of Internati · 130 participants
4 Large controlled trial Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study.
2026 · Aesthetic surgery journal · 174 participants · manufacturer helped fund this
4 Large controlled trial Effects of Heat-Killed Lactobacillus acidophilus IDCC 3302 on Skin Aging Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults.
2026 · Nutrients · 100 participants · manufacturer helped fund this
4 Large controlled trial A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.
2026 · Nutrients · 112 participants · manufacturer helped fund this
4 Large controlled trial Transitioning from Anti-aging to Skin Activation: Limiting Cellular Fatigue and Senescence for Skin Longevity.
2026 · Journal of drugs in dermatology : JDD · 400 participants
4 Large controlled trial Comparing patient satisfaction and pain control between vibration and topical anesthesia during botulinum toxin A injections: a randomized, double-blind, split-face clinical trial.
2026 · Journal of cosmetic and laser therapy : official publication · 100 participants
4 Large controlled trial Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.
2026 · Aesthetic surgery journal · 100 participants · manufacturer helped fund this
4 Large controlled trial Assessment of skin photoaging with reflectance confocal microscopy.
2015 · Skin research and technology : official journal of Internati · 120 participants
4 Large controlled trial A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin.
2015 · Journal of cosmetic dermatology · 120 participants
4 Large controlled trial Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms.
2024 · Biomolecules · 104 participants
4 Large controlled trial Autologous cultured fibroblast injection for facial contour deformities: a prospective, placebo-controlled, Phase III clinical trial.
2007 · Dermatologic surgery : official publication for American Soc · 215 participants
4 Large controlled trial Validation of digital photographic reference scales for evaluating facial aging signs.
2018 · Skin research and technology : official journal of Internati · 350 participants
4 Large controlled trial Long-term results for incobotulinumtoxinA in the treatment of glabellar frown lines.
2013 · Dermatologic surgery : official publication for American Soc · 796 participants
4 Large controlled trial A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.
2010 · The British journal of dermatology · 196 participants
4 Large controlled trial Juvéderm injectable gel: a multicenter, double-blind, randomized study of safety and effectiveness.
2009 · Aesthetic surgery journal · 292 participants
4 Large controlled trial Combination 532-nm and 1064-nm lasers for noninvasive skin rejuvenation and toning.
2003 · Archives of dermatology · 150 participants
4 Large controlled trial Can the effectiveness of health promotion campaigns be improved using self-efficacy and self-affirmation interventions? An analysis of sun protection messages.
2012 · Psychology & health · 677 participants
4 Large controlled trial A Novel Matrikine-Like Micro-Protein Complex (MPC) Technology for Topical Skin Rejuvenation.
2017 · Journal of drugs in dermatology : JDD · 133 participants
4 Large controlled trial ArteFill: a long-lasting injectable wrinkle filler material--summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes.
2006 · Plastic and reconstructive surgery · 251 participants
4 Large controlled trial Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler.
2008 · Dermatologic surgery : official publication for American Soc · 149 participants
4 Large controlled trial Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions.
1999 · Dermatology (Basel, Switzerland) · 355 participants
4 Large controlled trial Does hormone therapy improve age-related skin changes in postmenopausal women? A randomized, double-blind, double-dummy, placebo-controlled multicenter study assessing the effects of norethindrone acetate and ethinyl estradiol in the improvement of mild to moderate age-related skin changes in postmenopausal women.
2008 · Journal of the American Academy of Dermatology · 165 participants
4 Large controlled trial Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial.
2010 · Dermatologic surgery : official publication for American Soc · 118 participants
4 Large controlled trial RimabotulinumtoxinB vs. onabotulinumtoxinA for the treatment of forehead lines: an evaluator-blind, randomized, pilot study.
2013 · Journal of the European Academy of Dermatology and Venereolo · 100 participants
4 Large controlled trial A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage.
2005 · Journal of the American Academy of Dermatology · 568 participants
4 Large controlled trial Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial.
2000 · Journal of the American Academy of Dermatology · 800 participants
4 Large controlled trial Climacteric skin ageing of the face--a prospective longitudinal comparative trial on the effect of oral hormone replacement therapy.
1999 · Maturitas · 140 participants
4 Large controlled trial Application of a topical biomimetic electrical signaling technology to photo-aging: a randomized, double-blind, placebo-controlled trial of a galvanic zinc-copper complex.
2012 · Journal of drugs in dermatology : JDD · 124 participants
4 Large controlled trial "Multi Light and Drugs": a new technique to treat face photoaging. Comparative study with photorejuvenation.
2008 · Lasers in medical science · 100 participants
4 Large controlled trial Clinical panel assessment of photodamaged skin treated with isotretinoin using photographs.
1992 · Archives of dermatology · 326 participants