Treatments and supplements · Microneedling (standalone)
Does microneedling really help with wrinkles?
What we can tell you today: how thoroughly this has been studied.
The evidence stops at small studies
15 studies in people, but all of them small or without a comparison group. Enough to suspect something, too little to be sure.
3 Small study in people 15 studies
This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.
Appears under: Skin aging · Hair and nails
The studies
- 3 Small study in people
Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study.
2023 · Journal of cosmetic dermatology
- 3 Small study in people
Comparison of the effects of fractional microneedle radiofrequency and microneedling on modulating the senescent fibroblast milieu in aged skin.
2025 · Scientific reports · manufacturer helped fund this
- 3 Small study in people
Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial.
2025 · The Journal of dermatological treatment · 31 participants
- 3 Small study in people
Comparing the Effectiveness of Platelet-Rich Plasma Alone Versus Combined With Microneedles or Radiofrequency for Neck Wrinkle Treatment.
2025 · Journal of cosmetic dermatology
- 3 Small study in people
Microneedling Radiofrequency Enhances Poly-L-Lactic Acid Penetration That Effectively Improves Facial Skin Laxity without Lipolysis.
2024 · Plastic and reconstructive surgery · 32 participants
- 3 Small study in people
Evaluation of the Performance and Safety of a New Micro-Needle Technology in Comparison With the Classic Needle on the Antiaging Effects of a Biorevitalizing Solution: A Randomized Split Face/Neck Study.
2024 · Journal of cosmetic dermatology · manufacturer helped fund this
- 3 Small study in people
Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity.
2021 · International journal of cosmetic science
- 3 Small study in people
Microneedle fractional radiofrequency associated with drug delivery for facial atrophic acne scars and skin rejuvenation.
2024 · Journal of cosmetic and laser therapy : official public
- 3 Small study in people
Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.
2020 · Journal of cosmetic dermatology · manufacturer helped fund this
- 3 Small study in people
Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split-face comparative study.
2019 · International journal of dermatology
- 3 Small study in people
Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial.
2023 · Journal of cosmetic dermatology · 25 participants
- 3 Small study in people
An Exosome Regenerative Complex Plus Microneedling Promotes Hair Growth in Subjects With Self-Perceived Thinning Hair.
2025 · Journal of drugs in dermatology : JDD · 15 participants
- 3 Small study in people
Preliminary results of the use of scalp microneedling in different types of alopecia.
2020 · Journal of cosmetic dermatology
- 3 Small study in people
Efficacy and safety of microneedling and oral tranexamic acid in the treatment of facial melasma in women: An open, evaluator-blinded, randomized clinical trial.
2021 · Journal of the American Academy of Dermatology
- 3 Small study in people
Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single-blinded randomized clinical trial.
2021 · Dermatologic therapy · 80 participants