Treatments and supplements · Oral micronized progesterone

Does progesterone help with night sweats and sleep?

What we can tell you today: how thoroughly this has been studied.

Studied in controlled trials

8 studies, of which 7 are controlled trials in people with a hundred participants or more. No overview combining them yet.

4 Large controlled trial 7 studies

3 Small study in people 1 study

This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.

Appears under: Menopause and hormones

The studies

4 Large controlled trial Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial.
2023 · Scientific reports · 189 participants
4 Large controlled trial A 17β-Estradiol-Progesterone Oral Capsule for Vasomotor Symptoms in Postmenopausal Women: A Randomized Controlled Trial.
2019 · Obstetrics and gynecology · 250 participants
4 Large controlled trial Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study.
2018 · Menopause (New York, N.Y.) · 727 participants · manufacturer helped fund this
4 Large controlled trial Phase III comparison of depomedroxyprogesterone acetate to venlafaxine for managing hot flashes: North Central Cancer Treatment Group Trial N99C7.
2006 · Journal of clinical oncology : official journal of the · 109 participants
4 Large controlled trial Progesterone increases resistance of ophthalmic and central retinal arteries in climacteric women.
2013 · Climacteric : the journal of the International Menopaus · 108 participants
4 Large controlled trial Body mass index does not influence response to treatment, nor does body weight change with lower doses of conjugated estrogens and medroxyprogesterone acetate in early postmenopausal women.
2004 · Menopause (New York, N.Y.) · 822 participants
4 Large controlled trial A double-blind, randomized, comparative study evaluating clinical effects of two sequential estradiol-progestogen combinations containing either desogestrel or medroxyprogesterone acetate in climacteric women.
2000 · Maturitas · 190 participants
3 Small study in people Impact of Estradiol Variability and Progesterone on Mood in Perimenopausal Women With Depressive Symptoms.
2020 · The Journal of clinical endocrinology and metabolism