Treatments and supplements · Collagen dermal filler (injectable)

Do collagen injections still work as fillers?

What we can tell you today: how thoroughly this has been studied.

Studied in controlled trials

4 studies, of which 3 are controlled trials in people with a hundred participants or more. No overview combining them yet.

4 Large controlled trial 3 studies

3 Small study in people 1 study

This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.

Appears under: Skin aging

The studies

4 Large controlled trial Efficacy and Safety of Collagen Filler for Intradermal Injection: A Randomized Prospective Controlled Multicenter Study.
2025 · Aesthetic plastic surgery · 480 participants
4 Large controlled trial A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles.
2010 · Journal of the American Academy of Dermatology · 117 participants
4 Large controlled trial Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler.
2008 · Dermatologic surgery : official publication for America · 149 participants
3 Small study in people Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation.
2024 · Journal of cosmetic dermatology · 26 participants · manufacturer helped fund this