Does hyaluronic acid really hydrate?

Appears under: Skin aging

The studies

• 5 Repeated evidence The selection of hyaluronic acid when treating with the nasolabial fold: A meta-analysis.
  2022 · Journal of cosmetic dermatology · 1,190 participants
• 5 Repeated evidence Efficacy and Safety of Amino Acid-Enriched Hyaluronic Acid in Facial Rejuvenation: A Systematic Review and Meta-Analysis.
  2026 · Journal of cosmetic dermatology · 11 participants
• 4 Large controlled trial A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
  2023 · The Journal of dermatological treatment · 146 participants
• 4 Large controlled trial Prospective comparative clinical study: Efficacy evaluation of collagen combined with hyaluronic acid injections for tear trough deformity.
  2024 · Journal of cosmetic dermatology · 2,023 participants
• 4 Large controlled trial Efficacy and Safety of Two Resilient Hyaluronic Acid Fillers in the Treatment of Moderate-to-Severe Nasolabial Folds: A 64-Week, Prospective, Multicenter, Controlled, Randomized, Double-Blinded, and Within-Subject Study.
  2021 · Dermatologic surgery : official publication for America · 174 participants
• 4 Large controlled trial A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.
  2021 · Journal of cosmetic dermatology · 100 participants
• 4 Large controlled trial Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.
  2026 · Aesthetic surgery journal · 100 participants · manufacturer helped fund this
• 4 Large controlled trial Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial.
  2010 · Dermatologic surgery : official publication for America · 118 participants
• 3 Small study in people Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial.
  2022 · The Journal of dermatological treatment · 27 participants
• 3 Small study in people A Randomized, Evaluator-Blinded, Multicenter Study to Compare Injectable Poly-D,L-Lactic Acid vs Hyaluronic Acid for Nasolabial Fold Augmentation.
  2024 · Aesthetic surgery journal
• 3 Small study in people Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study.
  2023 · Journal of cosmetic dermatology · 20 participants
• 3 Small study in people Hand Rejuvenation with Customizable Hybrid Fillers: Premixed Calcium Hydroxyapatite and Hyaluronic Acid.
  2024 · Aesthetic plastic surgery
• 3 Small study in people Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity.
  2021 · International journal of cosmetic science
• 3 Small study in people High molecular weight hyaluronic acid vectorised with clay provides long-term hydration and reduces skin brightness.
  2024 · Skin research and technology : official journal of Inte
• 3 Small study in people Microinjections with hyaluronic acid in combination with glycerol: How do they influence biophysical viscoelastic skin properties?
  2022 · Skin research and technology : official journal of Inte · manufacturer helped fund this
• 3 Small study in people Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.
  2020 · Journal of cosmetic dermatology · manufacturer helped fund this
• 3 Small study in people A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler.
  2015 · Journal of drugs in dermatology : JDD