Treatments and supplements · Venlafaxine (Effexor)
Does venlafaxine help with hot flashes?
What we can tell you today: how thoroughly this has been studied.
Well studied
8 studies, including one that brings together the results of several trials in people.
5 Repeated evidence 1 study
4 Large controlled trial 6 studies
3 Small study in people 1 study
This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.
Appears under: Menopause and hormones
The studies
- 5 Repeated evidence
Efficacy and safety of desvenlafaxine treatment for hot flashes associated with menopause: a meta-analysis of randomized controlled trials.
2014 · Gynecologic and obstetric investigation
- 4 Large controlled trial
Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxine for vasomotor symptoms: a randomized clinical trial.
2014 · JAMA internal medicine · 146 participants · manufacturer helped fund this
- 4 Large controlled trial
Effects of estradiol and venlafaxine on insomnia symptoms and sleep quality in women with hot flashes.
2015 · Sleep · 325 participants
- 4 Large controlled trial
Desvenlafaxine compared with placebo for treatment of menopausal vasomotor symptoms: a 12-week, multicenter, parallel-group, randomized, double-blind, placebo-controlled efficacy trial.
2013 · Menopause (New York, N.Y.) · 365 participants
- 4 Large controlled trial
Phase III comparison of depomedroxyprogesterone acetate to venlafaxine for managing hot flashes: North Central Cancer Treatment Group Trial N99C7.
2006 · Journal of clinical oncology : official journal of the · 109 participants
- 4 Large controlled trial
Cardiovascular, cerebrovascular, and hepatic safety of desvenlafaxine for 1 year in women with vasomotor symptoms associated with menopause.
2013 · Menopause (New York, N.Y.) · 2,118 participants
- 4 Large controlled trial
Effect of desvenlafaxine on mood and climacteric symptoms in menopausal women with moderate to severe vasomotor symptoms.
2013 · Climacteric : the journal of the International Menopaus · 458 participants
- 3 Small study in people
Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial.
2010 · Journal of clinical oncology : official journal of the · 25 participants