Does calcium help with menopause symptoms or just bones?

What we can tell you today: how thoroughly this has been studied.

Well studied

9 studies, including one that brings together the results of several trials in people.

5 Repeated evidence 1 study

4 Large controlled trial 2 studies

3 Small study in people 6 studies

This says how thoroughly something has been studied — not whether it works for you. What each study actually found is in the study itself, and in the plain-language write-ups we are adding.

Appears under: Skin aging · Menopause and hormones · Hair and nails

The studies

5 Repeated evidence Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatite (CaHA) in the Face: A Systematic Review.
2026 · Aesthetic plastic surgery
4 Large controlled trial The severity of vasomotor symptoms and number of menopausal symptoms in postmenopausal women and select clinical health outcomes in the Women's Health Initiative Calcium and Vitamin D randomized clinical trial.
2021 · Menopause (New York, N.Y.) · 20,050 participants
4 Large controlled trial Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial.
2016 · Maturitas · 17,101 participants
3 Small study in people Gene Analysis of Biostimulators: Poly-L-Lactic Acid Triggers Regeneration While Calcium Hydroxylapatite Induces Inflammation Upon Facial Injection.
2025 · Journal of drugs in dermatology : JDD · 21 participants
3 Small study in people Comparative Bulk RNA-Seq Analysis of Poly-l-Lactic Acid Versus Calcium Hydroxylapatite Reveals a Novel, Adipocyte-Mediated Regenerative Mechanism of Action Unique to PLLA.
2024 · Dermatologic surgery : official publication for America · 21 participants
3 Small study in people Hand Rejuvenation with Customizable Hybrid Fillers: Premixed Calcium Hydroxyapatite and Hyaluronic Acid.
2024 · Aesthetic plastic surgery
3 Small study in people Combination of Calcium Hydroxylapatite Diluted With Normal Saline and Microfocused Ultrasound With Visualization for Skin Tightening.
2021 · Journal of drugs in dermatology : JDD · 20 participants
3 Small study in people A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler.
2015 · Journal of drugs in dermatology : JDD
3 Small study in people Calcium supplements and nail quality.
2000 · The New England journal of medicine