Clinical Features and Current Therapeutic Approaches to Monilethrix: A Systematic Review.
5 Repeated evidence
How much this weighs: several studies in people, combined — the strongest kind of evidence there is.
- Type of study
- meta-analysis or systematic review
- Studied in
- people
- Participants
- not stated in the abstract
- Published
- 2025 in Pediatric dermatology
- Cited
- 0 times by other research
- Who paid
- Not declared. PubMed carries no conflict-of-interest statement for most articles; that is not the same as independent.
- Source
- PubMed 40439138 · doi 10.1111/pde.15986
The plain-language write-up of this study is still being written.
Below is the abstract exactly as the researchers published it.
Abstract by the researchers — original text
Monilethrix is a rare congenital hair disorder characterized by fragile, beaded hair shafts due to mutations in various keratin or desmoglein 4 genes. A systematic review of 24 studies (16 pediatric only, 3 mixed adult and pediatric, 3 adult only, and 2 unspecified) evaluating various treatment modalities identified topical and oral minoxidil as the most effective therapies, while oral retinoids and other treatments showed variable efficacy. Further pediatric research and clinical studies are necessary to assess long-term treatment outcomes and explore novel therapeutic strategies for this challenging condition.