Topic

Living longer in good health

The 36 studies that carry the evidence on this topic, ordered by weight: the stronger the evidence and the more the study was built on, the higher it stands.

all levels level 5 · 164 level 4 · 36

4 Large controlled trial Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial.
2025 · JAMA · 2,111 participants · manufacturer helped fund this
4 Large controlled trial Efficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease.
2022 · Cardiovascular diabetology · 207 participants · manufacturer helped fund this
4 Large controlled trial Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: CENTRAL Magnetic Resonance Imaging Randomized Controlled Trial.
2019 · Circulation · 278 participants
4 Large controlled trial Cardiovascular mortality, all-cause mortality, and diabetes incidence after lifestyle intervention for people with impaired glucose tolerance in the Da Qing Diabetes Prevention Study: a 23-year follow-up study.
2015 · The lancet. Diabetes & endocrinology · 577 participants
4 Large controlled trial Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial.
2019 · JAMA neurology · 1,260 participants
4 Large controlled trial The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.
2023 · BMC medicine · 256 participants · manufacturer helped fund this
4 Large controlled trial Effect of exercise training for five years on all cause mortality in older adults-the Generation 100 study: randomised controlled trial.
2020 · BMJ (Clinical research ed.) · 1,567 participants
4 Large controlled trial White matter plasticity in healthy older adults: The effects of aerobic exercise.
2021 · NeuroImage · 180 participants
4 Large controlled trial Weight Loss in Underserved Patients - A Cluster-Randomized Trial.
2020 · The New England journal of medicine · 803 participants
4 Large controlled trial Healthy Lifestyle and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Study of the Efficacy of Fatty Liver Regression.
2025 · Clinical and translational gastroenterology · 150 participants
4 Large controlled trial Long-term Cumulative Incidence of Clinically Diagnosed Retinopathy in the Finnish Diabetes Prevention Study.
2025 · The Journal of clinical endocrinology and metabolism · 505 participants
4 Large controlled trial Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome.
2020 · Journal of the American Heart Association · 1,065 participants
4 Large controlled trial Effect of a 3-Year Lifestyle Intervention in Patients with Chronic Kidney Disease: A Randomized Clinical Trial.
2022 · Journal of the American Society of Nephrology : JASN · 160 participants
4 Large controlled trial Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial.
2024 · Cancer · 173 participants
4 Large controlled trial Effects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus: A Randomized Clinical Trial.
2020 · Circulation. Cardiovascular quality and outcomes · 502 participants
4 Large controlled trial Fasting Versus a Heart-Healthy Diet Before Cardiac Catheterization: A Randomized Controlled Trial.
2024 · American journal of critical care : an official publication, · 197 participants
4 Large controlled trial Prediction of disability-free survival in healthy older people.
2022 · GeroScience · 19,114 participants
4 Large controlled trial Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention.
2024 · The journal of nutrition, health & aging · 127 participants
4 Large controlled trial Effect of a comprehensive lifestyle intervention program on body weight and health behavior in women with breast cancer: Results from a randomized controlled trial.
2024 · Clinical nutrition (Edinburgh, Scotland) · 2,292 participants · manufacturer helped fund this
4 Large controlled trial Effect of long-term omega-3 supplementation and a lifestyle multidomain intervention on intrinsic capacity among community-dwelling older adults: Secondary analysis of a randomized, placebo-controlled trial (MAPT study).
2020 · Maturitas · 1,445 participants
4 Large controlled trial Findings from a pragmatic cluster randomised controlled feasibility trial of a music and dance programme for community dwelling older adults.
2024 · Archives of gerontology and geriatrics · 100 participants
4 Large controlled trial A lifestyle intervention of weight loss via a low-carbohydrate diet plus walking to reduce metabolic disturbances caused by androgen deprivation therapy among prostate cancer patients: carbohydrate and prostate study 1 (CAPS1) randomized controlled trial.
2020 · Prostate cancer and prostatic diseases · 100 participants
4 Large controlled trial Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome.
2021 · Clinical nutrition (Edinburgh, Scotland) · 489 participants
4 Large controlled trial Randomized Trial of a Lifestyle Intervention for Urban Low-Income African Americans with Type 2 Diabetes.
2020 · Journal of general internal medicine · 211 participants
4 Large controlled trial Gamifying Accelerometer Use Increases Physical Activity Levels of Sedentary Office Workers.
2019 · Journal of the American Heart Association · 146 participants
4 Large controlled trial Life Style Intervention Improves Retinopathy Status-The Finnish Diabetes Prevention Study.
2020 · Nutrients · 522 participants
4 Large controlled trial Remission of Type 2 Diabetes Following a Short-term Intervention With Insulin Glargine, Metformin, and Dapagliflozin.
2021 · The Journal of clinical endocrinology and metabolism · 154 participants
4 Large controlled trial Effectiveness of User- and Expert-Driven Web-based Hypertension Programs: an RCT.
2019 · American journal of preventive medicine · 128 participants
4 Large controlled trial Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial.
2022 · Aging clinical and experimental research · 1,260 participants
4 Large controlled trial A gender-sensitised weight-loss and healthy living program for men with overweight and obesity in Australian Football League settings (Aussie-FIT): A pilot randomised controlled trial.
2020 · PLoS medicine · 426 participants
4 Large controlled trial Behavioural intervention for weight loss maintenance versus standard weight advice in adults with obesity: A randomised controlled trial in the UK (NULevel Trial).
2019 · PLoS medicine · 288 participants
4 Large controlled trial Effectiveness of the Healthy Start-Départ Santé approach on physical activity, healthy eating and fundamental movement skills of preschoolers attending childcare centres: a randomized controlled trial.
2020 · BMC public health · 464 participants
4 Large controlled trial Social cognitive theory-based intervention to promote physical activity among prediabetic rural people: a cluster randomized controlled trial.
2019 · Trials · 272 participants
4 Large controlled trial Multiple health behaviour change primary care intervention for smoking cessation, physical activity and healthy diet in adults 45 to 75 years old (EIRA study): a hybrid effectiveness-implementation cluster randomised trial.
2022 · BMC public health · 3,062 participants
4 Large controlled trial Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.
2021 · Journal of Alzheimer's disease : JAD · 132 participants
4 Large controlled trial Eating self-efficacy changes in individuals with type 2 diabetes following a structured lifestyle intervention based on the transcultural Diabetes Nutrition Algorithm (tDNA): A secondary analysis of a randomized controlled trial.
2021 · PloS one · 230 participants