Topic
Sleep, energy and the brain
The 74 studies that carry the evidence on this topic, ordered by weight: the stronger the evidence and the more the study was built on, the higher it stands.
- 4 Large controlled trial
The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis.
2019 · The lancet. Psychiatry · 3,755 participants
- 4 Large controlled trial
The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis.
2026 · Sleep medicine · 102 participants
- 4 Large controlled trial
Cognitive behavioral therapy for insomnia has sustained effects on insomnia, fatigue, and function among people with chronic heart failure and insomnia: the HeartSleep Study.
2022 · Sleep · 175 participants
- 4 Large controlled trial
Assessment of an App-Based Sleep Program to Improve Sleep Outcomes in a Clinical Insomnia Population: Randomized Controlled Trial.
2025 · JMIR mHealth and uHealth · 132 participants
- 4 Large controlled trial
Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial.
2025 · Age and ageing · 161 participants
- 4 Large controlled trial
Depression prevention via digital cognitive behavioral therapy for insomnia: a randomized controlled trial.
2020 · Sleep · 358 participants
- 4 Large controlled trial
The effects of a sleep-focused smartphone application on insomnia and depressive symptoms: a randomised controlled trial and mediation analysis.
2023 · Journal of child psychology and psychiatry, and allied disci · 264 participants
- 4 Large controlled trial
Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial.
2020 · The American journal of clinical nutrition · 657 participants
- 4 Large controlled trial
Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial.
2009 · JAMA · 160 participants
- 4 Large controlled trial
Mindfulness-based therapy for insomnia for older adults with sleep difficulties: a randomized clinical trial.
2023 · Psychological medicine · 127 participants
- 4 Large controlled trial
Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial.
2025 · Journal of the American Medical Directors Association · 620 participants · manufacturer helped fund this
- 4 Large controlled trial
Efficacy of repetitive transcranial magnetic stimulation and agomelatine on sleep quality and biomarkers of adult patients with mild to moderate depressive disorder.
2023 · Journal of affective disorders · 100 participants
- 4 Large controlled trial
Cognitive-behavioral therapy for insomnia prevents and alleviates suicidal ideation: insomnia remission is a suicidolytic mechanism.
2022 · Sleep · 658 participants
- 4 Large controlled trial
Esketamine improves postoperative sleep quality in women undergoing gynecological laparoscopy: A prospective, randomized, double-blind, and controlled trial.
2025 · Sleep medicine · 150 participants
- 4 Large controlled trial
Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder.
2020 · Sleep medicine · 170 participants
- 4 Large controlled trial
The Effects of Vitamin D-Enriched Mushrooms and Vitamin D3 on Cognitive Performance and Mood in Healthy Elderly Adults: A Randomised, Double-Blinded, Placebo-Controlled Trial.
2021 · Nutrients · 436 participants
- 4 Large controlled trial
Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories.
2019 · Journal of consulting and clinical psychology · 148 participants
- 4 Large controlled trial
Dysfunctional beliefs and attitudes about sleep (DBAS) mediate outcomes in dCBT-I on psychological distress, fatigue, and insomnia severity.
2023 · Sleep medicine · 1,073 participants
- 4 Large controlled trial
Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
2024 · Frontiers in endocrinology · 320 participants
- 4 Large controlled trial
Sleep to Lower Elevated Blood Pressure: A Randomized Controlled Trial (SLEPT).
2018 · American journal of hypertension · 134 participants
- 4 Large controlled trial
Digital App Based Cognitive Behaviour Therapy CBT-I Course Improving Insomnia and Sleep Hygiene: A Randomised Controlled Trial.
2026 · Journal of sleep research · 191 participants · manufacturer helped fund this
- 4 Large controlled trial
Efficacy evaluation and facial expressions biomarker of light therapy in youths with subthreshold depression: A randomized control trial study.
2025 · Journal of affective disorders · 135 participants
- 4 Large controlled trial
The effect of sleep hygiene education on sleep quality and blood pressure in patients with essential hypertension in a family practice center: a randomized controlled trial.
2026 · Family practice · 138 participants
- 4 Large controlled trial
An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study.
2021 · Sleep medicine · 120 participants
- 4 Large controlled trial
Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment.
2021 · Journal of Alzheimer's disease : JAD · 196 participants
- 4 Large controlled trial
Cognitive-behavioral treatment for comorbid insomnia and osteoarthritis pain in primary care: the lifestyles randomized controlled trial.
2013 · Journal of the American Geriatrics Society · 2,011 participants
- 4 Large controlled trial
Cognition and Vitamin D in Older African-American Women- Physical performance and Osteoporosis prevention with vitamin D in older African Americans Trial and Dementia.
2019 · Journal of the American Geriatrics Society · 260 participants
- 4 Large controlled trial
Effect of melatonin on postoperative cognitive function in elderly patients submitted to transurethral resection of the prostate under spinal anesthesia.
2024 · Clinics (Sao Paulo, Brazil) · 118 participants
- 4 Large controlled trial
Impact of cognitive behavioral therapy for insomnia disorder on sleep and comorbid symptoms in military personnel: a randomized clinical trial.
2019 · Sleep · 151 participants
- 4 Large controlled trial
Effectiveness of one-week internet-delivered cognitive behavioral therapy for insomnia to prevent progression from acute to chronic insomnia: A two-arm, multi-center, randomized controlled trial.
2023 · Psychiatry research · 192 participants
- 4 Large controlled trial
Sleep-specific outcomes attributable to digitally delivered cognitive behavioral therapy for insomnia in adults with insomnia and depressive symptoms.
2024 · Behavioral sleep medicine · 1,149 participants · manufacturer helped fund this
- 4 Large controlled trial
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial.
2025 · PloS one · 322 participants
- 4 Large controlled trial
Feasibility of implementing a multi-component intervention of environmental control in mechanically ventilated ICU patients to improve sleep: A pilot randomized controlled trial.
2026 · Intensive & critical care nursing · 122 participants
- 4 Large controlled trial
High-Intensity Circuit Training Plus Sleep Health Intervention for Sleep Improvement: A Randomized Clinical Trial.
2026 · JAMA network open · 2,024 participants
- 4 Large controlled trial
A randomized controlled trial comparing sleep hygiene advice with a self-help book focusing on cognitive behavioral therapy for insomnia: a study among patients with prescribed hypnotics from the GP.
2026 · Scandinavian journal of primary health care · 125 participants
- 4 Large controlled trial
Cognitive Behavioral Therapy and Biofeedback for Chronic Headache: Effects on Pain Catastrophizing, Sleep Quality, and Disability.
2026 · Journal of clinical psychology in medical settings · 100 participants
- 4 Large controlled trial
The relationship between abdominal fat and sleep quality after combined exercise in patients with type 2 diabetes mellitus.
2025 · Frontiers in endocrinology · 100 participants
- 4 Large controlled trial
Impact of Fatty Acid Supplementation on Cognitive Performance among United States (US) Military Officers: The Ranger Resilience and Improved Performance on Phospholipid-Bound Omega-3's (RRIPP-3) Study.
2021 · Nutrients · 555 participants
- 4 Large controlled trial
Attribution, cognition and psychopathology in persistent insomnia disorder: outcome and mediation analysis from a randomized placebo-controlled trial of online cognitive behavioural therapy.
2015 · Sleep medicine · 164 participants
- 4 Large controlled trial
The effects of sleep hygiene education and reflexology on sleep quality and fatigue in patients receiving chemotherapy.
2019 · European journal of cancer care · 167 participants
- 4 Large controlled trial
Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials.
2009 · Lancet (London, England) · 106 participants
- 4 Large controlled trial
Effects of (non)deceptive placebos on reported sleep quality and food cue reactivity.
2024 · Journal of sleep research · 150 participants
- 4 Large controlled trial
Intraindividual variability in sleep schedule: effects of an internet-based cognitive-behavioral therapy for insomnia program and its relation with symptom remission.
2021 · Sleep · 303 participants
- 4 Large controlled trial
Effects of Additional Individually Tailored Interventions on Sick-Leave and Symptoms in Patients with Exhaustion Disorder: A Randomized Controlled Trial.
2022 · Journal of rehabilitation medicine · 142 participants
- 4 Large controlled trial
Rehabilitation for improved cognition in patients with stress-related exhaustion disorder: RECO - a randomized clinical trial.
2019 · Stress (Amsterdam, Netherlands) · 111 participants
- 4 Large controlled trial
Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial.
2021 · Brain and behavior · 168 participants
- 4 Large controlled trial
Distinguishing rumination from worry in clinical insomnia.
2010 · Behaviour research and therapy · 242 participants
- 4 Large controlled trial
Digital cognitive behaviour therapy for insomnia (dCBT-I): Chronotype moderation on intervention outcomes.
2022 · Journal of sleep research · 1,721 participants
- 4 Large controlled trial
Cognitive behavioral therapy for insomnia treatment attrition in patients with weekly nightmares.
2023 · Journal of clinical sleep medicine : JCSM : official publica · 110 participants
- 4 Large controlled trial
Who benefits from CBT for insomnia in primary care? Important patient selection and trial design lessons from longitudinal results of the Lifestyles trial.
2014 · Sleep · 2,011 participants
- 4 Large controlled trial
Omega-3 Supplementation for the Prevention of Cognitive Decline in Older Adults: Does It Depend on Homocysteine Levels?
2022 · The journal of nutrition, health & aging · 1,680 participants
- 4 Large controlled trial
The Effect of Tele-Savvy on Sleep Quality and Insomnia in Caregivers of Persons Living with Dementia.
2024 · Clinical interventions in aging · 137 participants
- 4 Large controlled trial
Psychometric Comparison of the Full and Abbreviated Versions of the Dysfunctional Beliefs and Attitudes about Sleep Scale.
2017 · Journal of clinical sleep medicine : JCSM : official publica · 312 participants
- 4 Large controlled trial
Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Trial.
2017 · Nutrients · 171 participants · manufacturer helped fund this
- 4 Large controlled trial
Trajectory of self-care in people with stable heart failure and insomnia after two self-care interventions.
2022 · Patient education and counseling · 175 participants
- 4 Large controlled trial
Group cognitive behavioural treatment for insomnia in primary care: a randomized controlled trial.
2016 · Psychological medicine · 239 participants
- 4 Large controlled trial
Long-Term Maintenance of Therapeutic Gains Associated With Cognitive-Behavioral Therapy for Insomnia Delivered Alone or Combined With Zolpidem.
2017 · Sleep · 160 participants
- 4 Large controlled trial
Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial.
2006 · Sleep · 184 participants
- 4 Large controlled trial
Cognitive behavioural therapy to treat stress and insomnia: A randomized wait list-controlled trial of two online courses.
2023 · Journal of sleep research · 588 participants
- 4 Large controlled trial
Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial.
2026 · Medicine · 135 participants · manufacturer helped fund this
- 4 Large controlled trial
Symphony of healing: Investigating the effects of integrating music therapy with cognitive behavioral therapy (CBT) and dynamic interpersonal therapy (DIT) on depression.
2025 · Psychiatry research · 230 participants
- 4 Large controlled trial
Sleep well and live well: Impact of sleep hygiene intervention on sleep duration in a rural community: A randomized controlled trial (THE SWELL STUDY).
2025 · The Journal of rural health : official journal of the Americ · 100 participants
- 4 Large controlled trial
Perioperative multimodal behavioral optimization improves recovery and long-term outcomes after curative gastrectomy: a randomized controlled trial.
2026 · Surgical endoscopy · 280 participants
- 4 Large controlled trial
Targeting hyperarousal to improve sleep: A network intervention analysis of a digital intervention for insomnia.
2026 · Behaviour research and therapy · 290 participants
- 4 Large controlled trial
The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial.
2026 · Alzheimer's & dementia : the journal of the Alzheimer's Asso · 100 participants
- 4 Large controlled trial
Effect of Sleep Report Feedback With Health Guidance Using a Sleep Monitoring Device for Improving Sleep in Community-Dwelling Older People: A Three-Arm Randomized Controlled Trial.
2026 · Geriatrics & gerontology international · 229 participants
- 4 Large controlled trial
Healing hearts and mending minds (FitBrain): a home-based aerobic exercise intervention to improve cognitive outcomes in older persons living with HIV.
2025 · AIDS care · 115 participants
- 4 Large controlled trial
Qinghao Biejia Decoction Combined with Auricular Acupoint Seed Embedding in Improving TCM Syndromes and Sleep Parameters in Perimenopausal Insomnia Patients.
2026 · Behavioral sleep medicine · 160 participants
- 4 Large controlled trial
Caffeine selectively mitigates cognitive deficits caused by sleep deprivation.
2021 · Journal of experimental psychology. Learning, memory, and co · 276 participants
- 4 Large controlled trial
A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic insomnia.
2007 · Current medical research and opinion · 100 participants
- 4 Large controlled trial
[Comparative study of the clinical efficacy and safety of the fixed dose combination Levroso Long with Melaxen and Diphenhydramine in patients with insomnia].
2023 · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 312 participants
- 4 Large controlled trial
Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial.
2015 · BMJ (Clinical research ed.) · 308 participants
- 4 Large controlled trial
Sleep locus of control and computerized cognitive-behavioral therapy (cCBT).
2010 · Behaviour research and therapy · 100 participants
- 4 Large controlled trial
Use of a post-sleep questionnaire-interactive voice response system (PSQ-IVRS) to evaluate the subjective sleep effects of ramelteon in adults with chronic insomnia.
2012 · Sleep medicine · 552 participants