Topic

Menopause and hormones

The 200 studies that carry the evidence on this topic, ordered by weight: the stronger the evidence and the more the study was built on, the higher it stands.

all levels level 5 · 70 level 4 · 108 level 3 · 22

5 Repeated evidence Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence.
2019 · Lancet (London, England)
5 Repeated evidence Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis.
2024 · BMC public health
5 Repeated evidence Systematic review and meta-analysis of the effects of menopause hormone therapy on cognition.
2024 · Frontiers in endocrinology
5 Repeated evidence Quality of life in postmenopausal women with osteoporosis: a systematic review and meta-analysis.
2023 · Quality of life research : an international journal of quali
5 Repeated evidence Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
2025 · Advances in nutrition (Bethesda, Md.) · 3,285 participants · manufacturer helped fund this
5 Repeated evidence Effects of mind-body exercise on perimenopausal and postmenopausal women: a systematic review and meta-analysis.
2024 · Menopause (New York, N.Y.) · 1,005 participants
5 Repeated evidence Long-term hormone therapy for perimenopausal and postmenopausal women.
2017 · The Cochrane database of systematic reviews · 43,637 participants
5 Repeated evidence Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations.
2020 · Journal of women's health (2002)
5 Repeated evidence Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis.
2025 · Obstetrics and gynecology · 4,087 participants
5 Repeated evidence Hormonal Treatments and Vaginal Moisturizers for Genitourinary Syndrome of Menopause : A Systematic Review.
2024 · Annals of internal medicine
5 Repeated evidence Vasomotor symptoms and risk of cardiovascular disease in peri- and postmenopausal women: A systematic review and meta-analysis.
2023 · Maturitas · 11 participants
5 Repeated evidence A systematic review and critical appraisal of menopause guidelines.
2024 · BMJ sexual & reproductive health · manufacturer helped fund this
5 Repeated evidence Global view of vasomotor symptoms and sleep disturbance in menopause: a systematic review.
2023 · Climacteric : the journal of the International Menopause Soc · 27 participants
5 Repeated evidence The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review.
2023 · Nutrients
5 Repeated evidence Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review.
2023 · Nutrients
5 Repeated evidence Exploring symptom clusters across the menopausal stages - systematic review and meta-analysis.
2025 · Sexual & reproductive healthcare : official journal of the S · 14,760 participants
5 Repeated evidence Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis.
2025 · Revista brasileira de ginecologia e obstetricia : revista da
5 Repeated evidence Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
2019 · Journal of medicinal food
5 Repeated evidence Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis.
2006 · JAMA
5 Repeated evidence Effects of nutritional interventions on the severity of depressive and anxiety symptoms of women in the menopausal transition and menopause: a systematic review, meta-analysis, and meta-regression.
2022 · Menopause (New York, N.Y.) · 16 participants
5 Repeated evidence Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes.
2005 · The Cochrane database of systematic reviews · manufacturer helped fund this
5 Repeated evidence Resistance training for postmenopausal women: systematic review and meta-analysis.
2022 · Menopause (New York, N.Y.) · 452 participants
5 Repeated evidence Hormone Therapy and Other Treatments for Symptoms of Menopause.
2017 · American family physician
5 Repeated evidence Neurokinin 1/3 receptor antagonists for menopausal women: A current systematic review and insights into the investigational non-hormonal therapy.
2023 · Medicine · 1,993 participants
5 Repeated evidence Estimation of placebo effect in randomized placebo-controlled trials for moderate or severe vasomotor symptoms: a meta-analysis.
2022 · Menopause (New York, N.Y.)
5 Repeated evidence Short-term and long-term effects of tibolone in postmenopausal women.
2016 · The Cochrane database of systematic reviews · 19,976 participants
5 Repeated evidence Systematic review of neurokinin-3 receptor antagonists for the management of vasomotor symptoms of menopause.
2024 · Menopause (New York, N.Y.)
5 Repeated evidence Complementary therapies for management of menopausal symptoms: a systematic review to inform the update of the International Menopause Society recommendations on women's midlife health.
2026 · Climacteric : the journal of the International Menopause Soc
5 Repeated evidence Cognitive behavioural therapy for menopausal symptoms: a systematic review of efficacy in improving quality of life.
2026 · BMC women's health · 910 participants
5 Repeated evidence Black cohosh (Cimicifuga spp.) for menopausal symptoms.
2012 · The Cochrane database of systematic reviews · 468 participants
5 Repeated evidence Using ginseng for menopausal women's health care: A systematic review of randomized placebo-controlled trials.
2022 · Complementary therapies in clinical practice · 515 participants
5 Repeated evidence Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause.
2018 · BJOG : an international journal of obstetrics and gynaecolog · 8,326 participants
5 Repeated evidence Efficacy of Low-Dose Paroxetine for the Treatment of Hot Flushes in Surgical and Physiological Postmenopausal Women: Systematic Review and Meta-Analysis of Randomized Trials.
2020 · Medicina (Kaunas, Lithuania)
5 Repeated evidence Comparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses.
2021 · Oncology nursing forum · manufacturer helped fund this
5 Repeated evidence Efficacy of mind-body therapies and exercise-based interventions on menopausal-related outcomes among Asian perimenopause women: A systematic review, meta-analysis, and synthesis without a meta-analysis.
2021 · Journal of advanced nursing
5 Repeated evidence Recommended measurement instruments for menopausal vasomotor symptoms: the COMMA (Core Outcomes in Menopause) consortium.
2024 · Menopause (New York, N.Y.) · 36 participants · manufacturer helped fund this
5 Repeated evidence Efficacy of plant-derived dietary supplements in improving overall menopausal symptoms in women: An updated systematic review and meta-analysis.
2024 · Phytotherapy research : PTR · 28 participants
5 Repeated evidence Use of interventions involving virtual reality tasks during the climacteric: a systematic review.
2022 · Climacteric : the journal of the International Menopause Soc
5 Repeated evidence The bidirectional relationship between vasomotor symptoms and depression across the menopausal transition: a systematic review of longitudinal studies.
2018 · Menopause (New York, N.Y.) · 10,008 participants
5 Repeated evidence The efficacy and tolerability of SSRI/SNRIs in the treatment of vasomotor symptoms in menopausal women: a systematic review.
2016 · Journal of the American Association of Nurse Practitioners
5 Repeated evidence The impact of cannabis use on vasomotor symptoms, mood, insomnia and sexuality in perimenopausal and postmenopausal women: a systematic review.
2022 · Climacteric : the journal of the International Menopause Soc
5 Repeated evidence Gabapentin for the treatment of hot flushes in menopause: a meta-analysis.
2020 · Menopause (New York, N.Y.)
5 Repeated evidence Acupuncture for menopausal hot flushes.
2013 · The Cochrane database of systematic reviews · 1,155 participants
5 Repeated evidence Dehydroepiandrosterone for women in the peri- or postmenopausal phase.
2017 · The Cochrane database of systematic reviews · 376 participants
5 Repeated evidence Chinese herbal medicine for menopausal symptoms.
2016 · The Cochrane database of systematic reviews · 2,902 participants
5 Repeated evidence NIH State-of-the-Science Conference Statement on management of menopause-related symptoms.
2007 · NIH consensus and state-of-the-science statements
5 Repeated evidence Testosterone use for hypoactive sexual desire disorder in postmenopausal women.
2023 · Menopause (New York, N.Y.)
5 Repeated evidence Does aromatherapy with lavender affect physical and psychological symptoms of menopausal women? A systematic review and meta-analysis.
2020 · Complementary therapies in clinical practice · 493 participants
5 Repeated evidence Mind-body interventions for vasomotor symptoms in healthy menopausal women and breast cancer survivors. A systematic review.
2018 · Journal of psychosomatic obstetrics and gynaecology · 7 participants
5 Repeated evidence Commonly used types of postmenopausal estrogen for treatment of hot flashes: scientific review.
2004 · JAMA
5 Repeated evidence The use of conjugated estrogens and bazedoxifene for the management of vasomotor symptoms in premenopausal and menopausal patients with endometriosis: a systematic review.
2026 · Climacteric : the journal of the International Menopause Soc
5 Repeated evidence Can massage ameliorate menopausal and postmenopausal symptoms in women? A systematic review and meta-analysis.
2026 · Complementary therapies in medicine
5 Repeated evidence The effectiveness of red clover on hot-flash in menopausal women: a GRADE-assessed systematic review and meta-analysis.
2026 · European journal of obstetrics, gynecology, and reproductive
5 Repeated evidence A systematic review of heart rate variability and menopausal vasomotor symptoms.
2026 · Physiological reports
5 Repeated evidence Kuntai capsule for the treatment of menopausal symptoms induced by GnRH-a therapy: A systematic review and meta-analysis of randomized controlled trials.
2025 · Journal of ethnopharmacology · 3,577 participants
5 Repeated evidence Is hypertension negatively associated with memory performance in women during climacteric? A systematic review.
2025 · BMC women's health
5 Repeated evidence Genetic Variation and Hot Flashes: A Systematic Review.
2021 · The Journal of clinical endocrinology and metabolism · 500 participants
5 Repeated evidence N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms.
2018 · International journal of molecular sciences
5 Repeated evidence The efficacy of purified pollen extract for reducing vasomotor symptoms in women: a systematic review and meta-analysis.
2024 · Menopause (New York, N.Y.) · 420 participants
5 Repeated evidence Psychoeducational interventions to alleviate hot flashes: a systematic review.
2008 · Menopause (New York, N.Y.) · 475 participants
4 Large controlled trial Efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms associated with menopause among women in East Asia: a phase 3 randomized study (MOONLIGHT I).
2024 · The Journal of international medical research · 301 participants · manufacturer helped fund this
5 Repeated evidence Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review.
2007 · Clinical therapeutics
4 Large controlled trial Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
2015 · JAMA psychiatry · 2,012 participants
5 Repeated evidence Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review.
2013 · Gynecological endocrinology : the official journal of the In
5 Repeated evidence Limitations in functioning in climacteric syndrome: a systematic literature review using the ICF.
2022 · Climacteric : the journal of the International Menopause Soc
5 Repeated evidence The Effect of Transdermal Estrogen Patch Use on Cardiovascular Outcomes: A Systematic Review.
2018 · Journal of women's health (2002)
5 Repeated evidence Short and long term effects of tibolone in postmenopausal women.
2012 · The Cochrane database of systematic reviews · 8,152 participants
5 Repeated evidence Efficacy and safety of desvenlafaxine treatment for hot flashes associated with menopause: a meta-analysis of randomized controlled trials.
2014 · Gynecologic and obstetric investigation
4 Large controlled trial Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study.
2021 · The journal of obstetrics and gynaecology research · 100 participants
5 Repeated evidence Clinical Inquiries: Does exercise relieve vasomotor menopausal symptoms?
2019 · The Journal of family practice
5 Repeated evidence Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms.
2009 · Alternative therapies in health and medicine · 56 participants
5 Repeated evidence Comparison of efficacy and local tolerability of estradiol metered-dose transdermal spray to estradiol patch in a network meta-analysis.
2017 · Climacteric : the journal of the International Menopause Soc
4 Large controlled trial Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxine for vasomotor symptoms: a randomized clinical trial.
2014 · JAMA internal medicine · 146 participants · manufacturer helped fund this
5 Repeated evidence Effects of low-dose norethindrone acetate plus ethinyl estradiol (0.5 mg/2.5 microg) in women with postmenopausal symptoms: updated analysis of three randomized, controlled trials.
2006 · Clinical therapeutics · 1,265 participants
4 Large controlled trial Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.
2011 · JAMA · 205 participants
4 Large controlled trial Fezolinetant impact on health-related quality of life for vasomotor symptoms due to the menopause: Pooled data from SKYLIGHT 1 and SKYLIGHT 2 randomised controlled trials.
2024 · BJOG : an international journal of obstetrics and gynaecolog · 1,022 participants · manufacturer helped fund this
4 Large controlled trial Hot flashes and sleep disruption in a randomized trial in menopausal women.
2024 · American journal of obstetrics and gynecology · 141 participants
4 Large controlled trial Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial.
2023 · Scientific reports · 189 participants
4 Large controlled trial A 17β-Estradiol-Progesterone Oral Capsule for Vasomotor Symptoms in Postmenopausal Women: A Randomized Controlled Trial.
2019 · Obstetrics and gynecology · 250 participants
4 Large controlled trial The effect of mandala coloring on anxiety and quality of life of women in the climacteric period: a randomized controlled study.
2024 · Revista da Associacao Medica Brasileira (1992) · 2,023 participants
4 Large controlled trial Effects of estrogen plus progestin on health-related quality of life.
2003 · The New England journal of medicine · 8,506 participants
4 Large controlled trial Psychometric evaluation of the HFDD, PROMIS SD SF 8b, and MENQOL questionnaire in women experiencing vasomotor symptoms associated with menopause.
2025 · Journal of patient-reported outcomes · 400 participants
4 Large controlled trial Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: a randomized, double-blind trial.
2011 · Archives of internal medicine · 2,009 participants
4 Large controlled trial Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study.
2018 · Menopause (New York, N.Y.) · 727 participants · manufacturer helped fund this
4 Large controlled trial The severity of vasomotor symptoms and number of menopausal symptoms in postmenopausal women and select clinical health outcomes in the Women's Health Initiative Calcium and Vitamin D randomized clinical trial.
2021 · Menopause (New York, N.Y.) · 20,050 participants
4 Large controlled trial Relationship between changes in vasomotor symptoms and changes in menopause-specific quality of life and sleep parameters.
2017 · Menopause (New York, N.Y.) · 318 participants
4 Large controlled trial Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial.
2009 · The Lancet. Oncology · 3,148 participants
4 Large controlled trial Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial.
2005 · Lancet (London, England) · 420 participants
4 Large controlled trial Effects of estradiol and venlafaxine on insomnia symptoms and sleep quality in women with hot flashes.
2015 · Sleep · 325 participants
4 Large controlled trial Menopausal quality of life: RCT of yoga, exercise, and omega-3 supplements.
2014 · American journal of obstetrics and gynecology · 338 participants
4 Large controlled trial Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report.
2019 · Menopause (New York, N.Y.) · 121 participants · manufacturer helped fund this
4 Large controlled trial Clinical Evaluation of Effectiveness and Safety of Combined Use of Dietary Supplements Amberen ® and Smart B ® in Women with Climacteric Syndrome in Perimenopause.
2024 · Advances in therapy · 106 participants
4 Large controlled trial Ultra-low-dose estradiol and dydrogesterone for treatment of vasomotor symptoms in Europe and China.
2024 · Climacteric : the journal of the International Menopause Soc · 579 participants
4 Large controlled trial Effect of aerobic training on hot flushes and quality of life--a randomized controlled trial.
2013 · Annals of medicine · 176 participants
4 Large controlled trial MsFLASH participants' priorities for alleviating menopausal symptoms.
2016 · Climacteric : the journal of the International Menopause Soc · 354 participants
4 Large controlled trial Metabolic and cardiovascular effects of TX-001HR in menopausal women with vasomotor symptoms.
2020 · Climacteric : the journal of the International Menopause Soc · 1,835 participants
4 Large controlled trial Effects of health education and progressive muscle relaxation on vasomotor symptoms and insomnia in perimenopausal women: A randomized controlled trial.
2022 · Patient education and counseling · 108 participants
4 Large controlled trial Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study.
2017 · Phytotherapy research : PTR · 115 participants
4 Large controlled trial Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1.
2006 · Journal of clinical oncology : official journal of the Ameri · 132 participants
4 Large controlled trial The effect of a randomized 12-week soy drink intervention on everyday mood in postmenopausal women.
2020 · Menopause (New York, N.Y.) · 101 participants
4 Large controlled trial A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency.
2012 · Journal of women's health (2002) · 102 participants
4 Large controlled trial Daily salivary cortisol patterns in midlife women with hot flashes.
2016 · Clinical endocrinology · 306 participants
4 Large controlled trial Menopausal symptom experience before and after stopping estrogen therapy in the Women's Health Initiative randomized, placebo-controlled trial.
2011 · Menopause (New York, N.Y.) · 3,496 participants
4 Large controlled trial Eszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trial.
2007 · Obstetrics and gynecology · 410 participants
4 Large controlled trial Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial.
2002 · JAMA · 2,325 participants
4 Large controlled trial Low-dose and ultra-low-dose estradiol and dydrogesterone in postmenopause: an analysis by body mass index.
2025 · Climacteric : the journal of the International Menopause Soc · 640 participants
4 Large controlled trial Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial.
2003 · JAMA · 252 participants
4 Large controlled trial Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS).
2013 · Fertility and sterility · 868 participants
4 Large controlled trial Effects of acupuncture on hot flashes in perimenopausal and postmenopausal women--a multicenter randomized clinical trial.
2010 · Menopause (New York, N.Y.) · 116 participants
4 Large controlled trial The TU-025 keishibukuryogan clinical trial for hot flash management in postmenopausal women: results and lessons for future research.
2011 · Menopause (New York, N.Y.) · 178 participants
4 Large controlled trial Menopausal symptoms in older women and the effects of treatment with hormone therapy.
2003 · Obstetrics and gynecology · 2,763 participants
4 Large controlled trial Desvenlafaxine compared with placebo for treatment of menopausal vasomotor symptoms: a 12-week, multicenter, parallel-group, randomized, double-blind, placebo-controlled efficacy trial.
2013 · Menopause (New York, N.Y.) · 365 participants
4 Large controlled trial A Multi-center, Randomized, Controlled and Open Clinical Trial of Heyan Kuntai Capsule () and Hormone Therapy in Perimenopausal Women.
2018 · Chinese journal of integrative medicine · 390 participants
4 Large controlled trial Effect of aerobic training on menopausal symptoms--a randomized controlled trial.
2012 · Menopause (New York, N.Y.) · 176 participants
4 Large controlled trial Hot flushes, coronary heart disease, and hormone therapy in postmenopausal women.
2019 · Menopause (New York, N.Y.) · 2,448 participants
4 Large controlled trial Effects of conjugated estrogens/bazedoxifene on lipid and coagulation variables: a randomized placebo- and active-controlled trial.
2016 · Menopause (New York, N.Y.) · 1,843 participants
4 Large controlled trial Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 2-year randomized, double-blind, placebo-controlled study.
2009 · Menopause (New York, N.Y.) · 389 participants
4 Large controlled trial Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women.
2008 · Menopause (New York, N.Y.) · 147 participants
4 Large controlled trial Persistent hot flushes in older postmenopausal women.
2008 · Archives of internal medicine · 375 participants
4 Large controlled trial Effects of tibolone on climacteric symptoms and quality of life in breast cancer patients--data from LIBERATE trial.
2012 · Maturitas · 3,148 participants
4 Large controlled trial Phase III comparison of depomedroxyprogesterone acetate to venlafaxine for managing hot flashes: North Central Cancer Treatment Group Trial N99C7.
2006 · Journal of clinical oncology : official journal of the Ameri · 109 participants
4 Large controlled trial Effects of low-dose paroxetine 7.5 mg on weight and sexual function during treatment of vasomotor symptoms associated with menopause.
2015 · Menopause (New York, N.Y.) · 1,175 participants
4 Large controlled trial Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopause women.
2011 · Revista da Associacao Medica Brasileira (1992) · 120 participants
4 Large controlled trial Sertraline to treat hot flashes: a randomized controlled, double-blind, crossover trial in a general population.
2006 · Menopause (New York, N.Y.) · 102 participants
4 Large controlled trial Evaluating the Sleep Hygiene Awareness and Practice Scale in Midlife Women With and Without Breast Cancer.
2017 · Journal of nursing measurement · 194 participants
4 Large controlled trial The effect of foot reflexology applied to women aged between 40 and 60 on vasomotor complaints and quality of life.
2017 · Complementary therapies in clinical practice · 120 participants
4 Large controlled trial Efficacy and tolerability of a novel estradiol vaginal ring for relief of menopausal symptoms.
2003 · Obstetrics and gynecology · 113 participants
4 Large controlled trial Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial.
2016 · Maturitas · 17,101 participants
4 Large controlled trial The effects of combined raloxifene and oral estrogen on vasomotor symptoms and endometrial safety.
2007 · Menopause (New York, N.Y.) · 123 participants
4 Large controlled trial Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile.
2014 · Clinical and experimental obstetrics & gynecology · 150 participants
4 Large controlled trial Progesterone increases resistance of ophthalmic and central retinal arteries in climacteric women.
2013 · Climacteric : the journal of the International Menopause Soc · 108 participants
4 Large controlled trial Prevention of osteoporosis and uterine effects in postmenopausal women taking raloxifene for 5 years.
2003 · Menopause (New York, N.Y.) · 185 participants
4 Large controlled trial Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial.
2007 · Menopause (New York, N.Y.) · 109 participants
4 Large controlled trial Long-term safety of drospirenone-estradiol for hormone therapy: a randomized, double-blind, multicenter trial.
2007 · Menopause (New York, N.Y.) · 1,147 participants
4 Large controlled trial Black cohosh and St. John's wort for climacteric complaints: a randomized trial.
2006 · Obstetrics and gynecology · 301 participants
4 Large controlled trial Design and baseline characteristics of the soy phytoestrogens as replacement estrogen (SPARE) study--a clinical trial of the effects of soy isoflavones in menopausal women.
2011 · Contemporary clinical trials · 283 participants
4 Large controlled trial Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study.
2010 · Menopause (New York, N.Y.) · 100 participants
4 Large controlled trial Cardiovascular, cerebrovascular, and hepatic safety of desvenlafaxine for 1 year in women with vasomotor symptoms associated with menopause.
2013 · Menopause (New York, N.Y.) · 2,118 participants
4 Large controlled trial Effect of desvenlafaxine on mood and climacteric symptoms in menopausal women with moderate to severe vasomotor symptoms.
2013 · Climacteric : the journal of the International Menopause Soc · 458 participants
4 Large controlled trial Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study.
2004 · Maturitas · 262 participants
4 Large controlled trial Estradiol 1 mg and drospirenone 2 mg as hormone replacement therapy in postmenopausal Chinese women.
2011 · Climacteric : the journal of the International Menopause Soc · 183 participants
4 Large controlled trial Transdermal estradiol gel for the treatment of symptomatic postmenopausal women.
2012 · Menopause (New York, N.Y.) · 119 participants
4 Large controlled trial Tibolone relieves climacteric symptoms in highly symptomatic women with at least seven hot flushes and sweats per day.
2005 · Maturitas · 770 participants
4 Large controlled trial Conjugated estrogens and bazedoxifene in minority populations: pooled analysis of four phase 3 trials.
2018 · Menopause (New York, N.Y.) · 2,907 participants
4 Large controlled trial Synthetic conjugated estrogens-B and postmenopausal nocturnal vasomotor symptoms: a randomized controlled trial.
2012 · Obstetrics and gynecology · 157 participants
4 Large controlled trial Body mass index does not influence response to treatment, nor does body weight change with lower doses of conjugated estrogens and medroxyprogesterone acetate in early postmenopausal women.
2004 · Menopause (New York, N.Y.) · 822 participants
4 Large controlled trial Evaluation of the direct and indirect effects of bazedoxifene/conjugated estrogens on sleep disturbance using mediation modeling.
2014 · Menopause (New York, N.Y.) · 1,843 participants
4 Large controlled trial Vasomotor hot flushes and 24-hour ambulatory blood pressure in normotensive women: A placebo-controlled trial on post-menopausal hormone therapy.
2010 · Annals of medicine · 147 participants
4 Large controlled trial Uterine and vaginal effects of unopposed ultralow-dose transdermal estradiol.
2005 · Obstetrics and gynecology · 417 participants
4 Large controlled trial The variable response of women with menopausal hot flashes when treated with sertraline.
2007 · Menopause (New York, N.Y.) · 102 participants
4 Large controlled trial The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulin.
2007 · Maturitas · 310 participants
4 Large controlled trial Effects of 5 years of hormonal replacement therapy on menopausal symptoms and blood pressure-a randomised controlled study.
2004 · Maturitas · 1,006 participants
4 Large controlled trial Vasomotor symptoms, adoption of a low-fat dietary pattern, and risk of invasive breast cancer: a secondary analysis of the Women's Health Initiative randomized controlled dietary modification trial.
2009 · Journal of clinical oncology : official journal of the Ameri · 45,160 participants
4 Large controlled trial Hot flushes and biochemical markers for cardiovascular disease: a randomized trial on hormone therapy.
2010 · Climacteric : the journal of the International Menopause Soc · 150 participants
4 Large controlled trial [Efficacy of standardized isoflavones extract (Soyfem) (52-104 mg/24h) in moderate and medium-severe climacteric syndrome].
2007 · Ginekologia polska · 169 participants
4 Large controlled trial The effect of a novel vaginal ring delivering oestradiol acetate on climacteric symptoms in postmenopausal women.
2003 · BJOG : an international journal of obstetrics and gynaecolog · 159 participants
4 Large controlled trial Bleeding patterns in peri and postmenopausal women taking a continuous combined regimen of estradiol with norethisterone acetate or a conventional sequential regimen of conjugated equine estrogens with medrogestone.
2003 · Maturitas · 446 participants
4 Large controlled trial Mammographic breast density and tolerance for short-term postmenopausal hormone therapy suspension.
2012 · Journal of women's health (2002) · 881 participants
4 Large controlled trial A study of the control of climacteric symptoms in postmenopausal women following sequential regimens of 1 mg 17beta-estradiol and trimegestone compared with a regimen containing 1 mg estradiol valerate and norethisterone over a two-year period.
2006 · Gynecological endocrinology : the official journal of the In · 531 participants
4 Large controlled trial Efficacy of a new, oral estradiol acetate formulation for relief of menopause symptoms.
2006 · Menopause (New York, N.Y.) · 293 participants
4 Large controlled trial Do combinations of 1 mg estradiol and low doses of NETA effectively control menopausal symptoms?
2002 · Climacteric : the journal of the International Menopause Soc · 119 participants
4 Large controlled trial Continuous combined hormone replacement therapy compared with tibolone.
1999 · Obstetrics and gynecology · 119 participants
4 Large controlled trial Use of dietary supplements and medication among postmenopausal women with vasomotor symptoms.
2011 · Climacteric : the journal of the International Menopause Soc · 331 participants
4 Large controlled trial Efficacy and tolerability of pulsed estrogen therapy: a 12-week double-blind placebo-controlled study in highly symptomatic postmenopausal women.
2003 · Climacteric : the journal of the International Menopause Soc · 165 participants
4 Large controlled trial Efficacy of sustained-release vaginal oestriol in alleviating urogenital and systemic climacteric complaints.
1991 · Maturitas · 109 participants
4 Large controlled trial A low-dose start in hormone replacement therapy provides a beneficial bleeding profile and few side-effects: randomized comparison with a conventional-dose regimen.
2004 · Climacteric : the journal of the International Menopause Soc · 132 participants
4 Large controlled trial Relief of hot flushes with new plant-derived 10-component synthetic conjugated estrogens.
2004 · Obstetrics and gynecology · 281 participants
4 Large controlled trial Acceptability and patterns of endometrial bleeding in estradiol-based HRT regimens: a comparative study of cyclical sequential combinations of trimegestone or norethisterone acetate.
2002 · Climacteric : the journal of the International Menopause Soc · 487 participants
4 Large controlled trial Efficacy on climacteric symptoms and safety of low dose estradiol transdermal matrix patches. A randomized, double-blind placebo-controlled study.
2000 · Arzneimittel-Forschung · 156 participants
4 Large controlled trial Perimenopausal women in estrogen vasomotor trials: contribution to placebo effect and efficacy outcome.
2001 · Climacteric : the journal of the International Menopause Soc · 109 participants
4 Large controlled trial Transition from estrogen-progestin to raloxifene in postmenopausal women: effect on vasomotor symptoms.
2004 · Obstetrics and gynecology · 266 participants
4 Large controlled trial [Effectiveness and tolerance of pulsed estrogen therapy in the treatment of menopausal symptoms. Results of a Polish multicenter study].
2005 · Ginekologia polska · 309 participants
4 Large controlled trial A double-blind, randomized, comparative study evaluating clinical effects of two sequential estradiol-progestogen combinations containing either desogestrel or medroxyprogesterone acetate in climacteric women.
2000 · Maturitas · 190 participants
4 Large controlled trial Continuous versus cyclical transdermal estrogen replacement therapy in postmenopausal women: influence on climacteric symptoms, body weight and bleeding pattern.
1998 · Maturitas · 2,459 participants
4 Large controlled trial [The effect of hormonal replacement therapy on symptoms of climacteric syndrome and selected metabolic parameters].
2001 · Ginekologia polska · 112 participants
4 Large controlled trial [Combination of hormone replacement therapy with buspirone in the treatment of climacteric complaints].
2000 · Orvosi hetilap · 100 participants
4 Large controlled trial [Effect of combined conjugated estrogen-medrogestone replacement therapy on lipid profiles, climacteric symptoms and the endometrium].
2000 · Journal de gynecologie, obstetrique et biologie de la reprod · 195 participants
4 Large controlled trial [Splenopeptides for climacteric complaints. Comparison of ovarian stimulation with transdermal estradiol substitution].
1995 · Arzneimittel-Forschung · 256 participants
3 Small study in people Hormone therapy in the postmenopausal years: considering benefits and risks in clinical practice.
2022 · Human reproduction update
3 Small study in people Effect of a lavender essential oil and sleep hygiene protocol on insomnia in postmenopausal women: A pilot randomized clinical trial.
2024 · Explore (New York, N.Y.) · 35 participants
3 Small study in people Impact of Estradiol Variability and Progesterone on Mood in Perimenopausal Women With Depressive Symptoms.
2020 · The Journal of clinical endocrinology and metabolism
3 Small study in people Investigating the effects of Pilates exercises on menopausal symptoms and sexual dysfunction in postmenopausal women: A randomized controlled trial.
2025 · Medicine
3 Small study in people Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study.
2017 · Maturitas
3 Small study in people A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome. An exploratory analysis.
2023 · Complementary therapies in medicine · 84 participants
3 Small study in people Exit Interviews Examining Changes to Mood and Work/Productivity Impacts Related to Vasomotor Symptoms: Perspectives of Postmenopausal Women Receiving Elinzanetant in Phase III Clinical Trials.
2025 · The patient
3 Small study in people Effects of an equol-containing supplement on advanced glycation end products, visceral fat and climacteric symptoms in postmenopausal women: A randomized controlled trial.
2021 · PloS one · manufacturer helped fund this
3 Small study in people Treatment and resource utilization for menopausal symptoms in the United States: a retrospective review of real-world evidence from US electronic health records.
2022 · Menopause (New York, N.Y.) · 1,016 participants · manufacturer helped fund this
3 Small study in people Retrospective analysis of phytoSERM for management of menopause-associated vasomotor symptoms and cognitive decline: a pilot study on pharmacogenomic effects of mitochondrial haplogroup and APOE genotype on therapeutic efficacy.
2021 · Menopause (New York, N.Y.) · 46 participants
3 Small study in people Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women.
1997 · The New England journal of medicine
3 Small study in people Dietary advanced glycation end-products and postmenopausal hot flashes: A post-hoc analysis of a 12-week randomized clinical trial.
2023 · Maturitas · 84 participants
3 Small study in people Women's views about physical activity as a treatment for vasomotor menopausal symptoms: a qualitative study.
2021 · BMC women's health
3 Small study in people The Women's Study for the Alleviation of Vasomotor Symptoms (WAVS): a randomized, controlled trial of a plant-based diet and whole soybeans for postmenopausal women.
2021 · Menopause (New York, N.Y.) · 38 participants · manufacturer helped fund this
3 Small study in people Vaginal microbiota and genitourinary menopausal symptoms: a cross-sectional analysis.
2018 · Menopause (New York, N.Y.) · 88 participants
3 Small study in people Effect of Bazedoxifene and Conjugated Estrogen (Duavee) on Breast Cancer Risk Biomarkers in High-Risk Women: A Pilot Study.
2020 · Cancer prevention research (Philadelphia, Pa.)
3 Small study in people Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial.
2010 · Journal of clinical oncology : official journal of the Ameri · 25 participants
3 Small study in people The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial.
2020 · Complementary therapies in medicine
3 Small study in people Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women's Health Initiative (WHI).
2021 · The Journal of clinical endocrinology and metabolism · 1,206 participants
3 Small study in people Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women: A randomized, double-blinded, placebo-controlled study.
2021 · Journal of food biochemistry · 48 participants
3 Small study in people Efficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post-menopausal hot flashes: a double-blind, randomized, placebo-controlled trial.
2019 · Archives of gynecology and obstetrics
3 Small study in people Estrogen replacement in perimenopause-related depression: a preliminary report.
2000 · American journal of obstetrics and gynecology